Crystallization (Comment) | Organism |
---|---|
enzyme in complex with orotate, crystal structure analysis, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,5-dihydrofuro[3,4-d]pyrimidine-2,4,7-trione | - |
Homo sapiens | |
2,3-dihydrotriazolo[4,5-d]pyrimidine-5,7-dione | - |
Homo sapiens | |
2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid | - |
Homo sapiens | |
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
5-[(dimethylamino)methyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
7,9-dihydro-3H-purine-2,6,8-trione | - |
Homo sapiens | |
butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate | - |
Homo sapiens | |
additional information | inhibitor virtual screening, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | anchored | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dihydroorotate + fumarate | Homo sapiens | - |
orotate + succinate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | Q4D3W2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dihydroorotate + fumarate | - |
Homo sapiens | orotate + succinate | - |
? | |
additional information | three-dimensional active site structure, profile of interactions for molecular recognition, interaction of DHODH with orotate via residues Asn212, Asn284, Ser215, Phe149, Lys100, Gly148, Asn217, Asn145, and Thr285, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure comparisons of enzymes from Trypanosoma cruzi, Leishmania major, and Homo sapiens, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DHODH | - |
Homo sapiens |
More | class 2 DHODH family enzyme | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |