Cloned (Comment) | Organism |
---|---|
gene cig5, expression of viperin lacking the leucine zipper domain, viperin43-340, in Escherichia coli Rosetta(DE3)pLysS cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | [4Fe-4S]1+ cluster and [3Fe-4S]1+ cluster | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
coproporphyrinogen III + 2 S-adenosyl-L-methionine | Homo sapiens | - |
protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene cig5 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
coproporphyrinogen III + 2 S-adenosyl-L-methionine | - |
Homo sapiens | protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine | - |
? | |
coproporphyrinogen III + 2 S-adenosyl-L-methionine | reductive cleavage of S-adenosyl-L-methionine to produce methionine and a 5'-deoxyadenosyl radical intermediate, a reaction characteristic of the radical SAM superfamily, due to the presence of a CX3CX2C motif | Homo sapiens | protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine | detection of the cleavage and degradation products and analysis by mass spectrometry, overview | ? |
Synonyms | Comment | Organism |
---|---|---|
viperin | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
[3Fe-4S]1+ cluster | - |
Homo sapiens | |
[4Fe-4S]1+ cluster | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the interferon-inducible antiviral protein viperin is a radical SAM enzyme, immune response pathway involving viperin that leads to the disruption of viral release from the plasma membrane, overview | Homo sapiens |