Organism | UniProt | Comment | Textmining |
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General Information | Comment | Organism |
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metabolism | SDH inhibition plays a role in metabolic suppression during hibernation and topor, overview. Oxaloacetate reversibly inhibits SDH in torpor, but cannot fully account for the drastic metabolic suppression observed during this hibernation phase. During arousal from the torpor phase of hibernation this suppression is reversed and metabolic rates rise dramatically | Ictidomys tridecemlineatus |
physiological function | SDH catalyzes the oxidation of succinate to fumarate in the matrix of the mitochondrion, donating electrons to ubiquinone that subsequently enter into the electron transport chain | Ictidomys tridecemlineatus |