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Literature summary for 1.3.99.23 extracted from

  • Schupp, M.; Lefterova, M.I.; Janke, J.; Leitner, K.; Cristancho, A.G.; Mullican, S.E.; Qatanani, M.; Szwergold, N.; Steger, D.J.; Curtin, J.C.; Kim, R.J.; Suh, M.J.; Suh, M.; Albert, M.R.; Engeli, S.; Gudas, L.J.; Lazar, M.A.
    Retinol saturase promotes adipogenesis and is downregulated in obesity (2009), Proc. Natl. Acad. Sci. USA, 106, 1105-1110.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
peroxisome proliferator activated receptor gamma PPARgamma Mus musculus
peroxisome proliferator activated receptor gamma PPARgamma Homo sapiens
thiazolidinedione
-
Mus musculus
thiazolidinedione
-
Homo sapiens

Application

Application Comment Organism
medicine RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease Mus musculus
medicine RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
E34A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Mus musculus
E34A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Homo sapiens
E96A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Mus musculus
E96A mutant, mutation within the highly conserved region of the dinucleotide-binding motif Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
determined by SDS-PAGE and Western Blot analysis Mus musculus
60000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinol + reduced acceptor Mus musculus
-
all-trans-13,14-dihydroretinol + acceptor
-
?
all-trans-retinol + reduced acceptor Homo sapiens
-
all-trans-13,14-dihydroretinol + acceptor
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-
adipocyte
-
Mus musculus
-
adipocyte
-
Homo sapiens
-
BOSC-23 cell
-
Homo sapiens
-
HEK-293T cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinol + reduced acceptor
-
Mus musculus all-trans-13,14-dihydroretinol + acceptor
-
?
all-trans-retinol + reduced acceptor
-
Homo sapiens all-trans-13,14-dihydroretinol + acceptor
-
?

Synonyms

Synonyms Comment Organism
retinol saturase
-
Mus musculus
retinol saturase
-
Homo sapiens
RetSat
-
Mus musculus
RetSat
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD FAD/NAD dinucleotide binding motif Mus musculus
FAD FAD/NAD dinucleotide binding motif Homo sapiens
NAD+ FAD/NAD dinucleotide binding motif Mus musculus
NAD+ FAD/NAD dinucleotide binding motif Homo sapiens

Expression

Organism Comment Expression
Mus musculus in adipocytes down-regulated in obesity down
Homo sapiens in adipocytes down-regulated in obesity down
Mus musculus incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes up
Homo sapiens incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes up