Activating Compound | Comment | Organism | Structure |
---|---|---|---|
peroxisome proliferator activated receptor gamma | PPARgamma | Mus musculus | |
peroxisome proliferator activated receptor gamma | PPARgamma | Homo sapiens | |
thiazolidinedione | - |
Mus musculus | |
thiazolidinedione | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease | Mus musculus |
medicine | RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E34A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Mus musculus |
E34A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Homo sapiens |
E96A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Mus musculus |
E96A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
60000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + reduced acceptor | Mus musculus | - |
all-trans-13,14-dihydroretinol + acceptor | - |
? | |
all-trans-retinol + reduced acceptor | Homo sapiens | - |
all-trans-13,14-dihydroretinol + acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
adipocyte | - |
Homo sapiens | - |
BOSC-23 cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + reduced acceptor | - |
Mus musculus | all-trans-13,14-dihydroretinol + acceptor | - |
? | |
all-trans-retinol + reduced acceptor | - |
Homo sapiens | all-trans-13,14-dihydroretinol + acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
retinol saturase | - |
Mus musculus |
retinol saturase | - |
Homo sapiens |
RetSat | - |
Mus musculus |
RetSat | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | FAD/NAD dinucleotide binding motif | Mus musculus | |
FAD | FAD/NAD dinucleotide binding motif | Homo sapiens | |
NAD+ | FAD/NAD dinucleotide binding motif | Mus musculus | |
NAD+ | FAD/NAD dinucleotide binding motif | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | in adipocytes down-regulated in obesity | down |
Homo sapiens | in adipocytes down-regulated in obesity | down |
Mus musculus | incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes | up |
Homo sapiens | incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes | up |