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Literature summary for 1.3.99.23 extracted from

  • Moise, A.R.; Lobo, G.P.; Erokwu, B.; Wilson, D.L.; Peck, D.; Alvarez, S.; Dominguez, M.; Alvarez, R.; Flask, C.A.; de Lera, A.R.; von Lintig, J.; Palczewski, K.
    Increased adiposity in the retinol saturase-knockout mouse (2010), FASEB J., 24, 1261-1270.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.99.23

Protein Variants

Protein Variants Comment Organism
additional information generation of RetSat-/- mice, phenotype in comparison to wild-type mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-all-trans-13,14-dihydroretinol + acceptor Mus musculus retinol saturase catalyzes the saturation of all-trans-retinol to produce (R)-all-trans-13,14-dihydroretinol all-trans-retinol + reduced acceptor
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 r

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6 mice
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-all-trans-13,14-dihydroretinol + acceptor retinol saturase catalyzes the saturation of all-trans-retinol to produce (R)-all-trans-13,14-dihydroretinol Mus musculus all-trans-retinol + reduced acceptor
-
 r

Synonyms

Synonyms Comment Organism
retinol saturase
-
 Mus musculus
RetSat
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 Mus musculus

General Information

General Information Comment Organism
additional information RetSat deficiency leads to up-regulation of PPARgamma and PPARgamma target expression Mus musculus
physiological function RetSat is required for adipocyte differentiation in the 3T3-L1 cell culture model, analysis of the mechanism involved in this putative proadipogenic effect of RetSat, overview. RetSat-null mice have normal levels of retinol and retinyl palmitate in liver, serum, and adipose tissue, but, in contrast to wild-type mice, are deficient in the production of all-trans-13,14-dihydroretinol from dietary vitamin A. Despite accumulating more fat, RetSat-null mice maintained on either low-fat or high-fat diets gain weight and have similar rates of food intake as age- and gender-matched wild-type control littermates, ablation of RetSat does not result in alterations in total body weight gain but could still affect the relative composition and size of adipose stores, phenotype, overview Mus musculus