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Literature summary for 1.3.99.5 extracted from

  • Elzanaty, S.; Giwercman, Y.L.; Giwercman, A.
    Significant impact of 5alpha-reductase type 2 polymorphisms on sperm concentration and motility (2006), Int. J. Androl., 29, 414-420.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme isoform 2 gene variants are associated with sperm concentration and motility, but not with epidymal and accessory sex gland markers Homo sapiens

Protein Variants

Protein Variants Comment Organism
A49T naturally occuring mutation of isoform 2, associated with significantly higher sperm concentration than wild-type Homo sapiens
V89L naturally occuring mutation of isoform 2, correlates with significantly higher proportion of progressive motile spermatozoa than wild-type Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
semen
-
Homo sapiens
-