Cloned (Comment) | Organism |
---|---|
sterol regulatory element binding proteins, SREBPs, regulate expression of Srd5a2. 293T cells are transfected with the Srd5a2 promoter-luciferase reporter and flag-pCDNA3.1+ SREBP-2 plasmids. SREBP-2 binds to the promoter for Srd5a2 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male B6/129 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
prostate | high expression level of Srd5a2 | Mus musculus | - |
skin | high expression level of Srd5a2 | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
SRD5A2 | - |
Mus musculus |
steroid 5-alpha reductase type 2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | Srd5a2 is induced in livers and prostate from mice fed a chow diet supplemented with lovastatin plus ezitimibe, which increases the activity of nuclear SREBP-2, induction of Srd5a2 through SREBP-2, SREBP-2 binds to the promoter for Srd5a2 | up |
General Information | Comment | Organism |
---|---|---|
additional information | sterol regulatory element binding proteins, SREBPs, regulate expression of Srd5a2 | Mus musculus |
physiological function | Srd5a2 catalyzes the irreversible conversion of testosterone to 5alpha-dihydrotestosterone in the male reproductive tract and is highly expressed in androgensensitive tissues such as the prostate and skin | Mus musculus |