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Literature summary for 1.3.99.5 extracted from

  • Seo, Y.-K.; Zhu, B.; Jeon, T.-I.; Osborne, T.F.
    Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin (2009), Exp. Cell Res., 315, 3133-3139.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
sterol regulatory element binding proteins, SREBPs, regulate expression of Srd5a2. 293T cells are transfected with the Srd5a2 promoter-luciferase reporter and flag-pCDNA3.1+ SREBP-2 plasmids. SREBP-2 binds to the promoter for Srd5a2 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
male B6/129 mice
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Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
prostate high expression level of Srd5a2 Mus musculus
-
skin high expression level of Srd5a2 Mus musculus
-

Synonyms

Synonyms Comment Organism
SRD5A2
-
Mus musculus
steroid 5-alpha reductase type 2
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Mus musculus

Expression

Organism Comment Expression
Mus musculus Srd5a2 is induced in livers and prostate from mice fed a chow diet supplemented with lovastatin plus ezitimibe, which increases the activity of nuclear SREBP-2, induction of Srd5a2 through SREBP-2, SREBP-2 binds to the promoter for Srd5a2 up

General Information

General Information Comment Organism
additional information sterol regulatory element binding proteins, SREBPs, regulate expression of Srd5a2 Mus musculus
physiological function Srd5a2 catalyzes the irreversible conversion of testosterone to 5alpha-dihydrotestosterone in the male reproductive tract and is highly expressed in androgensensitive tissues such as the prostate and skin Mus musculus