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Literature summary for 1.3.99.5 extracted from

  • Langlois, V.S.; Zhang; D.; Cooke, G.M.; Trudeau, V.L.
    Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase (2010), Gen. Comp. Endocrinol., 166, 489-497.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group Gallus gallus
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group Mus musculus
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group Rattus norvegicus
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group Danio rerio
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group Xenopus tropicalis
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group. SRD5alpha1 is located on chromosome 5p15 whereas SRD5alpha2 is located on 2p22, and SRD5alpha3 is located at 4q12 Canis lupus familiaris
phylogenetic analysis of SRD5alpha, overview. SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group. SRD5alpha1 is located on chromosome 5p15 whereas SRD5alpha2 is located on 2p22, and SRD5alpha3 is located at 4q12 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
catechin from green tea, Camellia sinensis, is specific for SRD5alpha1 inhibition Homo sapiens
dutasteride
-
Canis lupus familiaris
dutasteride
-
Danio rerio
dutasteride
-
Gallus gallus
dutasteride SRD5alpha2 and SRD5alpha1 both respond similarly to dutasteride Homo sapiens
dutasteride
-
Mus musculus
dutasteride
-
Rattus norvegicus
dutasteride
-
Xenopus tropicalis
finasteride SRD5alpha2 is more sensitive to finasteride than SRD5alpha1 Canis lupus familiaris
finasteride
-
Danio rerio
finasteride
-
Gallus gallus
finasteride SRD5alpha2 is more sensitive to finasteride than SRD5alpha1 Homo sapiens
finasteride
-
Mus musculus
finasteride both SRD5alpha subtypes 1 and 2 are inhibited Rattus norvegicus
finasteride
-
Xenopus tropicalis
gamma-linolenic acid a natural product found in oil of evening primrose, Oenothera biennis, oil and borage, Borago officinalis, inhibits SRD5alpha1 and SRD5alpha2 Homo sapiens
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Canis lupus familiaris
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Danio rerio
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Gallus gallus
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Homo sapiens
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Mus musculus
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Rattus norvegicus
additional information 4-aza-3-oxo-1-ene compounds are the major class of synthetic SRD5alpha inhibitors, they require a structure similar to 3-oxo-4-ene with a secondary 17beta-substituent to successfully bind to the SRD5alpha-NADPH or SRD5alpha-NADP+ complexes Xenopus tropicalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information under optimal conditions, SRD5alpha2 has a higher Vm/Km and a 1000fold greater affinity for steroid substrates than SRD5alpha1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-
Danio rerio
-
isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-
Gallus gallus
-
isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-
Homo sapiens P31213 gene SRD5A2; isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-
Mus musculus
-
isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-
Rattus norvegicus
-
isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-
Xenopus tropicalis
-
isozymes SRD5alpha1, SRD5alpha2, and SRD5alpha3
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo SRD5alpha3 occurs in whole embryo and larvae bodies Xenopus tropicalis
-
larva SRD5alpha3 occurs in whole embryo and larvae bodies Xenopus tropicalis
-
prostate SRD5alpha2 is mainly associated with androgen target tissues, e.g. prostate Homo sapiens
-
skin SRD5alpha1 is mostly high in none androgen target tissues, e.g. skin Homo sapiens
-

Synonyms

Synonyms Comment Organism
SRD5alpha
-
Gallus gallus
SRD5alpha
-
Mus musculus
SRD5alpha
-
Rattus norvegicus
SRD5alpha
-
Danio rerio
SRD5alpha
-
Xenopus tropicalis
SRD5alpha SRD5alpha enzymes form the oxidoreductase superfamily Canis lupus familiaris
SRD5alpha SRD5alpha enzymes form the oxidoreductase superfamily Homo sapiens
steroid-5alpha-reductase
-
Gallus gallus
steroid-5alpha-reductase
-
Mus musculus
steroid-5alpha-reductase
-
Rattus norvegicus
steroid-5alpha-reductase
-
Canis lupus familiaris
steroid-5alpha-reductase
-
Danio rerio
steroid-5alpha-reductase
-
Xenopus tropicalis
steroid-5alpha-reductase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 5.5 SRD5alpha2 has a sharp pH-optimum Homo sapiens
6 8.5 SRD5alpha1 has a broad pH range Homo sapiens
6.9
-
SRD5alpha3 Homo sapiens

General Information

General Information Comment Organism
evolution steroid-5alpha-reductases, SRD5alpha, and steroid-5beta-reductase, SRD5beta, represent a convergence in evolution. Phylogenetic analysis of SRD5alpha reveals that SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group, overview. An eukaryotic ancestor likely underwent duplication events to generate these three subfamilies (type 1/2, type 3 and GPSN2 ancestors), both SRD5alpha type 1/2 and GPSN2 subfamilies may have evolved by ancient duplication events at the early stage of vertebrate and chordate evolution Canis lupus familiaris
evolution steroid-5alpha-reductases, SRD5alpha, and steroid-5beta-reductase, SRD5beta, represent a convergence in evolution. Phylogenetic analysis of SRD5alpha reveals that SRD5alpha subfamilies include, not only the well-known SRD5alpha type 1, type 2 and type 3, but also the synaptic glycoprotein (GPSN2)/trans-2,3-enoly-CoA reductase group, overview. An eukaryotic ancestor likely underwent duplication events to generate these three subfamilies (type 1/2, type 3 and GPSN2 ancestors), both SRD5alpha type 1/2 and GPSN2 subfamilies may have evolved by ancient duplication events at the early stage of vertebrate and chordate evolution Homo sapiens
metabolism in vertebrates, SRD5alpha and SRD5beta are involved in C-19 and C-21 steroid biosynthesis, bile acid biosynthesis and erythropoiesis Canis lupus familiaris
metabolism in vertebrates, SRD5alpha and SRD5beta are involved in C-19 and C-21 steroid biosynthesis, bile acid biosynthesis and erythropoiesis Homo sapiens
additional information comparison of evolution, tissue distribution, enzyme characteristics and biological functions of SRD5alpha and SRD5beta, overview Canis lupus familiaris
additional information comparison of evolution, tissue distribution, enzyme characteristics and biological functions of SRD5alpha and SRD5beta, overview Homo sapiens
physiological function human SRD5alpha deficiencies can lead to pseudohermaphroditism, prostate cancer, polycystic ovarian syndrome and hirsutism. SRD5alpha-deficient patients exhibiting male pseudohermaphrodite phenotype lack the SRD5alpha2 isoform, but exhibited SRD5alpha1 activity Homo sapiens