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Literature summary for 1.4.1.1 extracted from

  • Brunhuber, N.M.W.; Blanchard, J.S.
    The biochemistry and enzymology of amino acid dehydrogenases (1994), Crit. Rev. Biochem. Mol. Biol., 29, 415-467.
    View publication on PubMed
Search for more literature for 1.4.1.1

Inhibitors

Inhibitors Comment Organism Structure
L-Ala
-
 Anabaena cylindrica
L-Ala
-
 Bacillus licheniformis
L-Ala reductive amination of pyruvate Kitasatospora aureofaciens
L-Ala
-
 Pseudomonas sp.
Mercurials
-
 Anabaena cylindrica
Mercurials
-
 Bacillus subtilis
Mercurials
-
 Lysinibacillus sphaericus
Mercurials
-
 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.023
-
 NADH
-
 Bacillus subtilis
0.029
-
 NADH
-
 Kitasatospora aureofaciens
0.031
-
 NADH
-
 Halobacterium salinarum
0.035
-
 NADH
-
 Bacillus subtilis
0.035
-
 NADH
-
 Thermus thermophilus
0.037
-
 NADH
-
 Bacillus cereus
0.059
-
 NADH
-
 Pseudomonas sp.
0.086
-
 NADH
-
 Bacillus japonicum
0.11
-
 NAD+
-
 Kitasatospora aureofaciens
0.11
-
 pyruvate
-
 Anabaena cylindrica
0.12
-
 NAD+
-
 Thermus thermophilus
0.18
-
 NAD+
-
 Bacillus subtilis
0.18
-
 NAD+
-
 Bacillus cereus
0.18
-
 L-Ala
-
 Thermus thermophilus
0.2
-
 NAD+
-
 Bacillus japonicum
0.2
-
 NADH
-
 Halobacterium salinarum
0.48
-
 pyruvate
-
 Bacillus cereus
0.49
-
 pyruvate
-
 Bacillus japonicum
0.5
-
 NAD+
-
 Halobacterium salinarum
0.54
-
 pyruvate
-
 Bacillus subtilis
0.56
-
 pyruvate
-
 Kitasatospora aureofaciens
0.75
-
 pyruvate
-
 Thermus thermophilus
0.8
-
 pyruvate
-
 Halobacterium salinarum
0.82
-
 NH4+
-
 Halobacterium salinarum
0.95
-
 pyruvate
-
 Halobacterium salinarum
1
-
 L-Ala
-
 Bacillus japonicum
1.5
-
 NAD+
-
 Halobacterium salinarum
1.73
-
 L-Ala
-
 Bacillus subtilis
4.3
-
 pyruvate
-
 Pseudomonas sp.
5
-
 L-Ala
-
 Kitasatospora aureofaciens
5.3
-
 L-Ala
-
 Halobacterium salinarum
6.67
-
 NH4+
-
 Kitasatospora aureofaciens
7
-
 L-Ala
-
 Halobacterium salinarum
8
-
 NH4+
-
 Anabaena cylindrica
8.9
-
 NH4+
-
 Bacillus japonicum
12.5
-
 L-Ala
-
 Bacillus cereus
26
-
 NH4+
-
 Pseudomonas sp.
30
-
 NH4+
-
 Bacillus cereus
38
-
 NH4+
-
 Bacillus subtilis
38
-
 NH4+
-
 Lysinibacillus sphaericus
59
-
 NH3
-
 Thermus thermophilus
500
-
 NH4+
-
 Halobacterium salinarum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
190000
-
-
 Bacillus japonicum

Organism

Organism UniProt Comment Textmining
Anabaena cylindrica
-
-
-
Bacillus cereus
-
-
-
Bacillus japonicum
-
-
-
Bacillus licheniformis
-
-
-
Bacillus subtilis
-
-
-
Geobacillus stearothermophilus
-
-
-
Halobacterium salinarum
-
-
-
Kitasatospora aureofaciens
-
-
-
Lysinibacillus sphaericus
-
-
-
Mycobacterium tuberculosis
-
-
-
Pseudomonas sp.
-
-
-
Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala + H2O + NAD+
-
 Bacillus subtilis pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Geobacillus stearothermophilus pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Lysinibacillus sphaericus pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Pseudomonas sp. pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Halobacterium salinarum pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Bacillus cereus pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Bacillus licheniformis pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+
-
 Bacillus japonicum pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+ highly specific for L-Ala Thermus thermophilus pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+ highly specific for L-Ala Mycobacterium tuberculosis pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+ highly specific for L-Ala Kitasatospora aureofaciens pyruvate + NH3 + NADH
-
 r
L-Ala + H2O + NAD+ highly specific for L-Ala Anabaena cylindrica pyruvate + NH3 + NADH
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 reductive amination Thermus thermophilus
8
-
 reductive amination Anabaena cylindrica
8.5
-
-
 Thermus thermophilus
8.5
-
 reductive amination of pyruvate Bacillus subtilis
8.5
-
 reductive amination of pyruvate Kitasatospora aureofaciens
8.5
-
 reductive amination of pyruvate Bacillus japonicum
9
-
 both directions Pseudomonas sp.
9
-
 both directions Halobacterium salinarum
9.3
-
 reductive amination Mycobacterium tuberculosis
9.6
-
 oxidative deamination Anabaena cylindrica
9.8
-
 oxidative deamination Mycobacterium tuberculosis
10
-
-
 Kitasatospora aureofaciens
10
-
-
 Bacillus japonicum
10 10.5 oxidative deamination Bacillus subtilis
10 10.5 oxidative deamination Lysinibacillus sphaericus
10 10.5 oxidative deamination Kitasatospora aureofaciens
10 10.5 oxidative deamination Bacillus japonicum
10.5
-
-
 Lysinibacillus sphaericus
10.5
-
 oxidative deamination of L-Ala Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Bacillus subtilis
NAD+
-
 Thermus thermophilus
NAD+
-
 Geobacillus stearothermophilus
NAD+
-
 Lysinibacillus sphaericus
NAD+
-
 Pseudomonas sp.
NAD+
-
 Halobacterium salinarum
NAD+
-
 Bacillus cereus
NAD+
-
 Mycobacterium tuberculosis
NAD+
-
 Bacillus licheniformis
NAD+
-
 Kitasatospora aureofaciens
NAD+
-
 Anabaena cylindrica
NAD+
-
 Bacillus japonicum
NADH
-
 Bacillus subtilis
NADH
-
 Thermus thermophilus
NADH
-
 Geobacillus stearothermophilus
NADH
-
 Lysinibacillus sphaericus
NADH
-
 Pseudomonas sp.
NADH
-
 Halobacterium salinarum
NADH
-
 Bacillus cereus
NADH
-
 Mycobacterium tuberculosis
NADH
-
 Bacillus licheniformis
NADH
-
 Kitasatospora aureofaciens
NADH
-
 Anabaena cylindrica
NADH
-
 Bacillus japonicum