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Literature summary for 1.4.1.15 extracted from

  • Buergi, W.; Richterich, R.; Colombo, J.P.
    L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance (1966), Nature, 211, 854-855.
    View publication on PubMed
Search for more literature for 1.4.1.15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + NAD+ Homo sapiens
-
 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 11.96 micromol/min*l homogenate, in the presence of cysteine Homo sapiens
additional information
-
 6.24 micromol/min*l homogenate, in the absence of cysteine Homo sapiens
additional information
-
 2.70 micromol/min*l homogenate, 3 months old baby girl with congenital lysine intolerance, in the presence of cysteine Homo sapiens
additional information
-
 0.874 micromol/min*l homogenate, 3 months old baby girl with congenital lysine intolerance, in the absence of cysteine Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + NAD+
-
 Homo sapiens 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens