Literature summary for 1.4.1.16 extracted from

Scapin, G.; Cirilli, M.; Reddy, S.G.; Gao, Y.; Vederas, J.C.; Blanchard, J.S.
Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase (1998), Biochemistry, 37, 3278-3285.

Search for more literature for 1.4.1.16

Cloned(Commentary)

Cloned (Comment)	Organism
-	Corynebacterium glutamicum

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals of the ternary complex formed from the enzyme, NADP+ and the inhibitor (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid	Corynebacterium glutamicum

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid	-	Corynebacterium glutamicum

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	P04964	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Corynebacterium glutamicum

Reaction

Reaction	Comment	Organism	Reaction ID
meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+	only amino acid dehydrogenase which stereospecifically oxidizes a D-stereocenter	Corynebacterium glutamicum	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	diaminopimelate synthesis is thermodynamically favoured	Corynebacterium glutamicum	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Corynebacterium glutamicum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0042	-	(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid	reductive amination	Corynebacterium glutamicum
0.023	-	(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid	oxidative deamination at pH 7.8	Corynebacterium glutamicum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)