Literature summary for 1.4.1.18 extracted from

Misono, H.; Nagasaki, S.
Distribution and physiological function of L-lysine epsilon-dehydrogenase (1983), Agric. Biol. Chem., 47, 631-633.

No PubMed abstract available

Search for more literature for 1.4.1.18

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-lysine + NAD+ + H2O	Alcaligenes faecalis	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Lysinibacillus sphaericus	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Klebsiella pneumoniae	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Pseudomonas fragi	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Agrobacterium tumefaciens	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Micrococcus sp.	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Morganella morganii	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Hafnia alvei	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Corynebacterium ammoniagenes	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Corynebacterium pseudodiphtheriticum	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Sinomonas atrocyanea	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Corynebacterium ammoniagenes IFO 12071	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Pseudomonas fragi IFO 3458	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Lysinibacillus sphaericus IFO 3525	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Sinomonas atrocyanea IFO 12670	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Alcaligenes faecalis IFO 3160	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Corynebacterium pseudodiphtheriticum ICR 2210	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	Morganella morganii IFO 3848	-	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?

Organism

Organism	UniProt	Comment	Textmining
Agrobacterium tumefaciens	-	activity depends on growth conditions	-
Alcaligenes faecalis	-	traces of activity	-
Corynebacterium ammoniagenes	-	low activity	-
Corynebacterium pseudodiphtheriticum	-	traces of activity	-
Hafnia alvei	-	Bacterium cadaveris, traces of activity	-
Klebsiella pneumoniae	-	Aerobacter aerogenes ICR 0220 and IFO 12059, traces of activity with strain IFO 3319	-
Lysinibacillus sphaericus	-	-	-
Micrococcus sp.	-	traces of activity in Micrococcus roseus and Micrococcus flavus	-
Morganella morganii	-	-	-
no activity in Bos taurus	-	liver	-
no activity in yeast	-	more than 20 different yeast tested for activity	-
Pseudomonas fragi	-	traces of activity	-
Sinomonas atrocyanea	-	traces of activity	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-lysine + NAD+ + H2O	-	Alcaligenes faecalis	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Lysinibacillus sphaericus	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Klebsiella pneumoniae	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Pseudomonas fragi	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Agrobacterium tumefaciens	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Micrococcus sp.	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Morganella morganii	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Hafnia alvei	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Corynebacterium ammoniagenes	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Corynebacterium pseudodiphtheriticum	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Sinomonas atrocyanea	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Corynebacterium ammoniagenes IFO 12071	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Pseudomonas fragi IFO 3458	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Lysinibacillus sphaericus IFO 3525	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Sinomonas atrocyanea IFO 12670	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Alcaligenes faecalis IFO 3160	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Corynebacterium pseudodiphtheriticum ICR 2210	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?
L-lysine + NAD+ + H2O	-	Morganella morganii IFO 3848	alpha-aminoadipate delta-semialdehyde + NH3 + NADH	product is spontaneosly converted into delta1-piperideine-6-carboxylate	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Alcaligenes faecalis
NAD+	-	Lysinibacillus sphaericus
NAD+	-	Klebsiella pneumoniae
NAD+	-	Pseudomonas fragi
NAD+	-	Agrobacterium tumefaciens
NAD+	-	Micrococcus sp.
NAD+	-	Morganella morganii
NAD+	-	Hafnia alvei
NAD+	-	Corynebacterium ammoniagenes
NAD+	-	Corynebacterium pseudodiphtheriticum
NAD+	-	Sinomonas atrocyanea

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Release 2023.1 (January 2023)