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Literature summary for 1.4.1.2 extracted from

  • Li, M.; Allen, A.; Smith, T.J.
    High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors (2007), Biochemistry, 46, 15089-15102.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.1.2

Activating Compound

Activating Compound Comment Organism Structure
ADP ADP can reverse inhibition Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid) i.e. BSB Bos taurus
ATP/GTP-competitive inhibitor of casein kinase-2
-
 Bos taurus
aurintricarboxylic acid
-
 Bos taurus
BH3I-2
-
 Bos taurus
bithionol
-
 Bos taurus
Calmidazolium
-
 Bos taurus
diethylstilbestrol
-
 Bos taurus
epicatechin
-
 Bos taurus
epicatechin-3-monogallate
-
 Bos taurus
epicatechin-monogallate
-
 Bos taurus
epigallocatechin
-
 Bos taurus
epigallocatechin-3,5-digallate
-
 Bos taurus
epigallocatechin-3-gallate
-
 Bos taurus
erythrosin B
-
 Bos taurus
ethaverine hydrochloride
-
 Bos taurus
gallic acid
-
 Bos taurus
GW-5074
-
 Bos taurus
Hexachlorophene
-
 Bos taurus
leoidin
-
 Bos taurus
metergoline
-
 Bos taurus
suloctidil
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD+
-
 Bos taurus 2-oxoglutarate + NH3 + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
GDH
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus epicatechin-3-monogallate
0.0005
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus epigallocatechin-3-monogallate
0.0012
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus aurintricarboxylic acid
0.0015
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus GW-5074
0.0017
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus diethylstilbestrol
0.0017
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus Hexachlorophene
0.0037
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus BH3I-2
0.0055
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus bithionol
0.0064
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus 3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid)
0.0077
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus Calmidazolium
0.0138
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus suloctidil
0.0158
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus ATP/GTP-competitive inhibitor of casein kinase-2
0.0328
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus metergoline
0.05
-
 IC50 above 0.05 mM, in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus erythrosin B
0.08
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus gallic acid