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Literature summary for 1.4.3.13 extracted from

  • Rodriguez, C.; Rodriguez-Sinovas, A.; Martinez-Gonzalez, J.
    Lysyl oxidase as a potential therapeutic target (2008), Drug News Perspect., 21, 218-224.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
tumor growth factor-beta1 stabilizes LOX mRNA leading to an increase in LOX activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptopyridine-N-oxide
-
Mus musculus
alpha2-Macroglobulin
-
Mus musculus
beta-aminopropionitrile
-
Mus musculus
heparin
-
Mus musculus
homocysteine thiolactone
-
Mus musculus
low-density lipoprotein down-regulates LOX expression Mus musculus
taurine
-
Mus musculus
tumor necrosis factor-alpha down-regulates LOX expression Mus musculus
vitamin B3
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ dependent Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
mature and catalytically active enzyme, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
LOX
-
Mus musculus
lysyl oxidase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
lysyl-tyrosyl-quinone
-
Mus musculus