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Literature summary for 1.4.3.2 extracted from
- Flavoprotein amino acid oxidases (1963), The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 7, 609-648.
No PubMed abstract available
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
- |
Crotalus adamanteus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzoic acid | - |
Agkistrodon piscivorus piscivorus |  |
| benzoic acid | - |
Crotalus adamanteus | |
| benzoic acid | - |
Rattus norvegicus | |
| CuSO4 | - |
Rattus norvegicus | |
| iodoacetic acid | - |
Agkistrodon piscivorus piscivorus | |
| iodoacetic acid | - |
Crotalus adamanteus | |
| iodoacetic acid | - |
Rattus norvegicus | |
| NH4+ | inhibition of amino acid oxidase activity, no inhibition of L-hydroxy acid oxidase activity | Agkistrodon piscivorus piscivorus | |
| NH4+ | inhibition of amino acid oxidase activity, no inhibition of L-hydroxy acid oxidase activity | Crotalus adamanteus | |
| NH4+ | inhibition of amino acid oxidase activity, no inhibition of L-hydroxy acid oxidase activity | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 138000 | - |
calculation from diffusion constant, sedimentation coefficient and FAD content | Rattus norvegicus |
| 150000 | - |
approach to equilibrium method | Agkistrodon piscivorus piscivorus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agkistrodon piscivorus piscivorus | - |
cottonmouth moccasin | - |
| Crotalus adamanteus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
- |
Crotalus adamanteus |
- |
Agkistrodon piscivorus piscivorus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 | mechanism | Rattus norvegicus | |
| an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 | mechanism | Crotalus adamanteus | |
| an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 | mechanism | Agkistrodon piscivorus piscivorus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| venom | - |
Crotalus adamanteus | - |
| venom | - |
Agkistrodon piscivorus piscivorus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-amino acid + H2O + O2 | - |
Crotalus adamanteus | 2-oxo acid + NH3 + H2O2 | - |
? | |
| L-amino acid + H2O + O2 | - |
Agkistrodon piscivorus piscivorus | 2-oxo acid + NH3 + H2O2 | - |
? | |
| L-amino acid + H2O + O2 | other electron acceptors: methylene blue | Rattus norvegicus | 2-oxo acid + NH3 + H2O2 | - |
? | |
| L-lactic acid + H2O + O2 | - |
Rattus norvegicus | pyruvate + NH3 + H2O2 | - |
? | |
| additional information | not: alpha-hydroxyisobutyrate | Rattus norvegicus | ? | - |
? | |
| additional information | proline and N-methyl derivatives of leucine, methionine, homocysteine and S-benzylhomocysteine also oxidized | Rattus norvegicus | ? | - |
? | |
| additional information | proline and N-methyl derivatives of leucine, methionine, homocysteine and S-benzylhomocysteine also oxidized | Crotalus adamanteus | ? | - |
? | |
| additional information | proline and N-methyl derivatives of leucine, methionine, homocysteine and S-benzylhomocysteine also oxidized | Agkistrodon piscivorus piscivorus | ? | - |
? | |
| additional information | not: D-amino acids, N,N-dimethylleucine, alpha-aminoisobutyric acid | Rattus norvegicus | ? | - |
? | |
| additional information | not: D-amino acids, N,N-dimethylleucine, alpha-aminoisobutyric acid | Crotalus adamanteus | ? | - |
? | |
| additional information | not: D-amino acids, N,N-dimethylleucine, alpha-aminoisobutyric acid | Agkistrodon piscivorus piscivorus | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
rapid loss of activity | Agkistrodon piscivorus piscivorus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 7.5 | - |
Rattus norvegicus |
| 7.2 | 7.5 | - |
Crotalus adamanteus |
| 7.2 | 7.5 | - |
Agkistrodon piscivorus piscivorus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
| FAD | 2 mol of FAD per mol of enzyme | Crotalus adamanteus | |
| FAD | 2 mol of FAD per mol of enzyme | Agkistrodon piscivorus piscivorus | |
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