Literature summary for 1.4.3.2 extracted from

Zhang, L.; Wei, L.J.
ACTX-8, a cytotoxic L-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells (2007), Life Sci., 80, 1189-1197.

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Application

Application	Comment	Organism
medicine	induces apoptosis in Hela cervical cancer cells in a concentration- and time-dependent manner. Caspase activation and PARP cleavage are involved in ACTX-8-induced apoptosis. ACTX-8 activates a mitochondrial pathway of apoptosis, which is regulated by Bcl-2 family members. Reactive oxygen species generated by ACTX-8 are involved in apoptosis. Translocation of Bax and Bad from the cytosol into mitochondria in ACTX-8-treated cells	Deinagkistrodon acutus

Organism

Organism	UniProt	Comment	Textmining
Deinagkistrodon acutus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
venom	-	Deinagkistrodon acutus	-

Synonyms

Synonyms	Comment	Organism
ACTX-8	-	Deinagkistrodon acutus

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Release 2023.1 (January 2023)