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Literature summary for 1.4.3.21 extracted from
- Substrate selectivity of monoamine oxidase A, monoamine oxidase B, diamine oxidase, and semicarbazide-sensitive amine oxidase in COS-1 expression systems (2006), Biol. Pharm. Bull., 29, 2362-2366.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | clorgyline and deprenyl do not significantly inhibit the activities | Rattus norvegicus | |
| Semicarbazide | causes significant decreases in the oxidative deamination activity of four among the five substrates catalyzed by SSAO | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | O08590 | nine-week-old male Wistar rats | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00015 | - |
substrate benzylamine, at low substrate concentration | Rattus norvegicus |
| 0.00023 | - |
substrate beta-phenylethylamine, at low substrate concentration | Rattus norvegicus |
| 0.00025 | - |
substrate tyramine, at low substrate concentration | Rattus norvegicus |
| 0.00078 | - |
substrate 1-methylhistamine, at low substrate concentration | Rattus norvegicus |
| 0.00108 | - |
substrate tyramine, at high substrate concentration | Rattus norvegicus |
| 0.00136 | - |
substrate beta-phenylethylamine, at high substrate concentration | Rattus norvegicus |
| 0.00165 | - |
substrate 1-methylhistamine, at high substrate concentration | Rattus norvegicus |
| 0.00193 | - |
substrate benzylamine, at high substrate concentration | Rattus norvegicus |
| 0.00388 | - |
substrate serotonin, at high substrate concentration | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methylhistamine + O2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| benzylamine + O2 + H2O | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| beta-phenylethylamine + O2 + H2O | - |
Rattus norvegicus | beta-phenylethanal + NH3 + H2O2 | - |
? | |
| serotonin + O2 + H2O | - |
Rattus norvegicus | (5-hydroxy-1H-indol-3yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| tyramine + O2 + H2O | - |
Rattus norvegicus | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| semicarbazide-sensitive amine oxidase | - |
Rattus norvegicus |
| SSAO | - |
Rattus norvegicus |
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