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Literature summary for 1.4.3.21 extracted from

  • Haider, N.; Hochholdinger, I.; Matyus, P.; Wobus, A.
    Synthesis of ortho-functionalized 4-aminomethylpyridazines as substrate-like semicarbazide-sensitive amine oxidase inhibitors (2010), Chem. Pharm. Bull., 58, 964-970.
    View publication on PubMed
Search for more literature for 1.4.3.21

Inhibitors

Inhibitors Comment Organism Structure
4-(aminomethyl)-2-benzyl-5-(ethylamino)pyridazin-3(2H)-one below 10% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-2-methyl-5-(morpholin-4-yl)pyridazin-3(2H)-one 93% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-2-methyl-5-(pyrrolidin-1-yl)pyridazin-3(2H)-one below 10% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-5-(ethylamino)-2-methylpyridazin-3(2H)-one 13% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-N,N-diethylpyridazine-3,5-diamine over 99% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-N,N'-diethylpyridazine-3,5-diamine
-
 Homo sapiens
4-(aminomethyl)-N-butylpyridazin-3-amine 27% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-N-ethylpyridazin-3-amine 29% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-N-methylpyridazin-3-amine 47% inhibition at 0.5 mM Homo sapiens
4-(aminomethyl)-N-propylpyridazin-3-amine 44% inhibition at 0.5 mM Homo sapiens
additional information inhibitor synthesis and screening, overview Homo sapiens
Semicarbazide
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
semicarbazide-sensitive amine oxidase
-
 Homo sapiens
SSAO
-
 Homo sapiens
VAP-1
-
 Homo sapiens
vascular adhesion protein 1
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-(aminomethyl)-N,N'-diethylpyridazine-3,5-diamine