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Literature summary for 1.4.3.21 extracted from

  • Foot, J.S.; Deodhar, M.; Turner, C.I.; Yin, P.; van Dam, E.M.; Silva, D.G.; Olivieri, A.; Holt, A.; McDonald, I.A.
    The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) (2012), Bioorg. Med. Chem. Lett., 22, 3935-3940.
    View publication on PubMed
Search for more literature for 1.4.3.21

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-fluoro-4-phenoxybut-2-en-1-amine
-
 Homo sapiens
(2E)-4-phenoxybut-2-en-1-amine
-
 Homo sapiens
(2Z)-3-fluoro-4-phenoxybut-2-en-1-amine
-
 Homo sapiens
(2Z)-4-phenoxybut-2-en-1-amine
-
 Homo sapiens
(4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]phenyl)(pyrrolidin-1-yl)methanone
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N,N-dimethylbenzamide
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-(1-phenylethyl)benzamide
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-benzyl-N-methylbenzamide
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-benzylbenzamide
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-cyclohexylbenzamide
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-cyclopentylbenzamide
-
 Homo sapiens
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]benzamide
-
 Homo sapiens
mofegiline
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
AOC3
-
 Homo sapiens
plasma amine oxidase
-
 Homo sapiens
primary amine oxidase
-
 Homo sapiens
semicarbazide-sensitive amine oxidase
-
 Homo sapiens
SSAO
-
 Homo sapiens
VAP-1
-
 Homo sapiens
vascular adhesion protein-1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-cyclohexylbenzamide
0.00002
-
 pH and temperature not specified in the publication Homo sapiens mofegiline
0.00002
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-cyclopentylbenzamide
0.00004
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-(1-phenylethyl)benzamide
0.00008
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-benzylbenzamide
0.00014
-
 pH and temperature not specified in the publication Homo sapiens (4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]phenyl)(pyrrolidin-1-yl)methanone
0.00026
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-benzyl-N-methylbenzamide
0.00029
-
 pH and temperature not specified in the publication Homo sapiens (2E)-3-fluoro-4-phenoxybut-2-en-1-amine
0.00037
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N,N-dimethylbenzamide
0.00107
-
 pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]benzamide
0.02
-
 pH and temperature not specified in the publication Homo sapiens (2Z)-3-fluoro-4-phenoxybut-2-en-1-amine
0.082
-
 pH and temperature not specified in the publication Homo sapiens (2E)-4-phenoxybut-2-en-1-amine
0.1
-
 IC 50 above 0.1 mM, pH and temperature not specified in the publication Homo sapiens (2Z)-4-phenoxybut-2-en-1-amine