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Literature summary for 1.4.3.22 extracted from
- Purification of histaminase (diamine oxidase) from human pregnancy plasma by affinity chromatography (1975), Biochim. Biophys. Acta, 397, 294-306.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aminoguanidine | 0.02 mM, complete inhibition, oxidation of histamine | Homo sapiens |  |
| Iproniazid | 0.1 mM, 68% inhibition | Homo sapiens | |
| NaCl | 200 mM, approx. 50% inhibition, almost complete inhibition of the purified enzyme with 1 M NaCl | Homo sapiens | |
| Semicarbazide | 0.1 mM, 99% inhibition, oxidation of histamine | Homo sapiens | |
| tranylcypromine | slight | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
2 * 90000, SDS-PAGE | Homo sapiens |
| 200000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity chromatography on cadaverine-Sepharose | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,4-diaminobutane + H2O + O2 | - |
Homo sapiens | 4-aminobutanal + NH3 + H2O2 | - |
? | |
| histamine + H2O + O2 | - |
Homo sapiens | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | no activity with benzylamine | Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 90000, SDS-PAGE | Homo sapiens |
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Release 2023.1 (January 2023)
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