Literature summary for 1.4.3.22 extracted from

Ochiai, Y.; Itoh, K.; Sakurai, E.; Adachi, M.; Tanaka, Y.
Substrate selectivity of monoamine oxidase A, monoamine oxidase B, diamine oxidase, and semicarbazide-sensitive amine oxidase in COS-1 expression systems (2006), Biol. Pharm. Bull., 29, 2362-2366.

Search for more literature for 1.4.3.22

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-1 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	clorgyline and deprenyl do not decrease DAO activity	Rattus norvegicus
Semicarbazide	very strong inhibition	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P36633	nine-week-old male Wistar rats	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00017	-	substrate histamine, at low substrate concentration	Rattus norvegicus
0.00037	-	substrate beta-phenylethylamine, at high substrate concentration	Rattus norvegicus
0.00074	-	substrate tyramine, at high substrate concentration	Rattus norvegicus
0.00075	-	substrate benzylamine, at high substrate concentration	Rattus norvegicus
0.00226	-	substrate histamine, at high substrate concentration	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzylamine + O2 + H2O	-	Rattus norvegicus	benzaldehyde + NH3 + H2O2	-	?
beta-phenylethylamine + O2 + H2O	-	Rattus norvegicus	beta-phenylethanal + NH3 + H2O2	-	?
histamine + O2 + H2O	DAO	Rattus norvegicus	(imidazol-4-yl)acetaldehyde + NH3 + H2O2	-	?
tyramine + O2 + H2O	-	Rattus norvegicus	1H-indol-3-ylacetaldehyde + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
DAO	-	Rattus norvegicus
Diamine oxidase	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)