Literature summary for 1.4.3.22 extracted from

Rajtar, S.; Irman-Florjanc, T.
Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs (2007), Eur. J. Pharmacol., 574, 201-208.

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Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	amitriptyline at 0.03, 0.05, 0.1 and 0.5 mM concentrations lower enzyme activity in the plasma of the heparinised rat by 14, 22, 23 and 28%, respectively	Rattus norvegicus	-
blood plasma	in vitro treatment with 100 nM, 0.05, 0.1 and 0.5 mM amitriptyline increases the guinea pig plasma diamine oxidase activity by 5, 7, 17 and 11%, respectively	Cavia porcellus	-

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Release 2023.1 (January 2023)