Literature summary for 1.4.3.3 extracted from

Sacchi, S.; Bernasconi, M.; Martineau, M.; Mothet, J.P.; Ruzzene, M.; Pilone, M.S.; Pollegioni, L.; Molla, G.
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: Effect on schizophrenia susceptibility (2008), J. Biol. Chem., 283, 22244-22256.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in glioblastoma cells	Homo sapiens
expressed in glioblastoma cells	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	bovine serum albumin does not affect DAAO activity	Sus scrofa
pLG72	acts as a negative effector of DAAO	Homo sapiens
pLG72	activity decreases in the presence of pLG72 (0.27 mg/ml)	Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
40000	-	2 * 40000, SDS-PAGE	Homo sapiens
40000	-	2 * 40000, SDS-PAGE	Sus scrofa
80000	-	SDS-PAGE	Homo sapiens
80000	-	SDS-PAGE	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Sus scrofa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens
-	Sus scrofa

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Homo sapiens	-
brain cortex	-	Homo sapiens	-
kidney	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-serine + H2O + O2	-	Homo sapiens	2-oxo-3-hydroxypropionic acid + NH3 + H2O2	-	?
D-serine + H2O + O2	-	Sus scrofa	2-oxo-3-hydroxypropionic acid + NH3 + H2O2	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 40000, SDS-PAGE	Homo sapiens
homodimer	2 * 40000, SDS-PAGE	Sus scrofa

Synonyms

Synonyms	Comment	Organism
D-amino acid oxidase	-	Homo sapiens
D-amino acid oxidase	-	Sus scrofa
DAAO	-	Homo sapiens
DAAO	-	Sus scrofa

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Homo sapiens
FAD	-	Sus scrofa

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Release 2023.1 (January 2023)