Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a potential therapeutic target for schizophrenia treatment | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
peroxisome | - |
Rattus norvegicus | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | O35078 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
flavoprotein | - |
Homo sapiens |
flavoprotein | - |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | in choroid plexus epithelial cells and glial cells of rhombencephalon. Higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases | Homo sapiens | - |
brain | in choroid plexus epithelial cells, glial cells of pons, medulla oblongata, and especially in Bergmann glia of cerebellum | Rattus norvegicus | - |
cerebellum | Bermann glia | Rattus norvegicus | - |
additional information | in situ hybridization and immunohistochemic determination | Homo sapiens | - |
additional information | in situ hybridization and immunohistochemic determination | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide | Homo sapiens | ? | - |
? | |
additional information | D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Homo sapiens |
DAO | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | flavoenzyme | Homo sapiens | |
flavin | flavoenzyme | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases | up |
General Information | Comment | Organism |
---|---|---|
malfunction | an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism | Homo sapiens |
physiological function | DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid | Homo sapiens |