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Literature summary for 1.4.3.4 extracted from

  • Houslay, M.D.; Tipton, K.F.
    A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes (1974), Biochem. J., 139, 645-652.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-Cyanophenol
-
Rattus norvegicus
benzyl cyanide reversible inhibitor Rattus norvegicus
Clorgyline MAO-A highly sensitive and MAO-B less sensitive to inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus
0.0159
-
5-methoxytryptamine
-
Rattus norvegicus
0.0185
-
tryptamine
-
Rattus norvegicus
0.0208
-
2-Phenylethylamine
-
Rattus norvegicus
0.0238
-
4-methoxy-2-phenylethylamine
-
Rattus norvegicus
0.187
-
5-hydroxytryptamine
-
Rattus norvegicus
0.245
-
benzylamine
-
Rattus norvegicus
0.282
-
tyramine
-
Rattus norvegicus
0.405
-
dopamine
-
Rattus norvegicus
0.475
-
4-hydroxy-3-methoxy-2-phenylethylamine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
Rattus norvegicus 5741
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethylamine + H2O + O2
-
Rattus norvegicus 2-phenylethanal + NH3 + H2O2
-
?
4-hydroxy-3-methoxy-2-phenylethylamine + H2O + O2
-
Rattus norvegicus ?
-
r
4-methoxy-2-phenylethylamine + H2O + O2
-
Rattus norvegicus ?
-
r
benzylamine + H2O + O2
-
Rattus norvegicus benzaldehyde + NH3 + H2O2
-
?
dopamine + H2O + O2
-
Rattus norvegicus (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
?
methoxytryptamine + H2O + O2
-
Rattus norvegicus ?
-
?
RCH2NH2 + H2O + O2 specificity Rattus norvegicus RCHO + NH3 + H2O2
-
?
RCH2NH2 + H2O + O2 5-hydroxytryptamine, MAO-A selective substrate Rattus norvegicus RCHO + NH3 + H2O2
-
?
RCH2NH2 + H2O + O2 4-hydroxy-3-methoxy-2-phenylethylamine, nonselective substrate, 4-methoxy-2-phenylethylamine, 5-methoxytryptamine Rattus norvegicus RCHO + NH3 + H2O2
-
?
serotonin + H2O + O2
-
Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
tryptamine + H2O + O2
-
Rattus norvegicus 1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
?
tyramine + H2O + O2
-
Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
More MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
lability increased at pH-values greater than 10 Rattus norvegicus