Application | Comment | Organism |
---|---|---|
analysis | both (R)-(-)- and (S)-(+)-1-(1-[11C]methyl-1H-pyrrol-2-yl)-2-phenyl-2-(1-pyrrolidinyl)ethanone are very promising tracers for positron emission tomography of the MAO-A enzyme in brain. The carbon-11-labeling reaction is fairly simple and robust. Yields of more than 1 GBq are routinely obtained and with high specific activity of the final product. The metabolism of (R)-(-)- and (S)-(+)-1-(1-[11C]methyl-1H-pyrrol-2-yl)-2-phenyl-2-(1-pyrrolidinyl)ethanone is relatively slow in plasma of living pigs, in contrast to [11C]harmine, which is difficult to detect in plasma at times after 10 min. Parametric maps of [11C](R)-(-)- and (S)-(+)-1-(1-[11C]methyl-1H-pyrrol-2-yl)-2-phenyl-2-(1-pyrrolidinyl)ethanone binding are qualitatively very comparable to those of [11C]harmine | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | Q6Q2J0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Sus scrofa | - |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Sus scrofa |