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Literature summary for 1.4.3.4 extracted from
- Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanide (2007), Neurochem. Res., 32, 1783-1790.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pheniprazine | i.e. (1-methyl-2-phenylethyl)hydrazine. Mechanism-based MAO inhibitor | Bos taurus |  |
| pheniprazine | i.e. (1-methyl-2-phenylethyl)hydrazine. As a reversible inhibitor it is selective towards rat liver MAO-A but the rate of irreversible inhibition of that enzyme is considerably slower; i.e. (1-methyl-2-phenylethyl)hydrazine. Mechanism-based MAO inhibitor | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | P56560 | - |
- |
| Rattus norvegicus | P19643 | - |
- |
| Rattus norvegicus | P21396 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzylamine + H2O + O2 | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| benzylamine + H2O + O2 | - |
Bos taurus | benzaldehyde + NH3 + H2O2 | - |
? | |
| serotonin + H2O + O2 | - |
Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| monoamine oxidase A | - |
Rattus norvegicus |
| monoamine oxidase B | - |
Rattus norvegicus |
| monoamine oxidase B | - |
Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00004 | - |
pheniprazine | in presence of 3 mM KCN | Rattus norvegicus | |
| 0.00005 | - |
pheniprazine | in presence of 2 mM KCN | Rattus norvegicus | |
| 0.00008 | - |
pheniprazine | in presence of 0.0125 mM KCN | Bos taurus | |
| 0.00009 | - |
pheniprazine | in presence of 0.01 mM KCN | Bos taurus | |
| 0.00025 | - |
pheniprazine | in presence of 0.007 mM KCN | Bos taurus | |
| 0.00029 | - |
pheniprazine | in presence of 1 mM KCN | Rattus norvegicus | |
| 0.00042 | - |
pheniprazine | without KCN | Rattus norvegicus | |
| 0.00045 | - |
pheniprazine | without KCN | Bos taurus | |
| 0.00075 | - |
pheniprazine | in presence of 0.005 mM KCN | Rattus norvegicus | |
| 0.00095 | - |
pheniprazine | in presence of 0.0035 mM KCN | Rattus norvegicus | |
| 0.00141 | - |
pheniprazine | in presence of 0.0025 mM KCN | Rattus norvegicus | |
| 0.00245 | - |
pheniprazine | without KCN | Rattus norvegicus | |
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