Activating Compound | Comment | Organism | Structure |
---|---|---|---|
SRY protein | SRY and Sp1 form a transcriptional complex and synergistically activate MAO A transcription, overview | Homo sapiens | |
transcription factor Sp1 | SRY and Sp1 form a transcriptional complex and synergistically activate MAO A transcription, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
MAO A is encoded on the X chromosome | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | successful SRY knockdown inhibits MAO A catalytic activity by 45% | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
serotonin + H2O + O2 | Homo sapiens | MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin. MAO A is a putative target gene directly regulated by a transcription factor encoded by the sex-determining region Y, SRY, gene located on the Y chromosome, via the functional SRY-binding site in the MAO A core promoter | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21397 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
SK-N-BE(2)C cell | male cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
serotonin + H2O + O2 | - |
Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
serotonin + H2O + O2 | MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin. MAO A is a putative target gene directly regulated by a transcription factor encoded by the sex-determining region Y, SRY, gene located on the Y chromosome, via the functional SRY-binding site in the MAO A core promoter | Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO A | - |
Homo sapiens |
monoamine oxidase A | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | a knockdown of SRY expression substantially reduces both MAO A 2- and 0.24-kb core-promoter activities to below 40% in the transfected cells, overview. R1, i.e. RAM2/CDCA7L/JPO2, a transcription repressor, downregulates MAO A gene expression by competing with Sp1 for binding to Sp1 sites | down |
Homo sapiens | stable overexpression of SRY in the BE(2)C cell line results in ibncreased MAO-A mRNA and catalytic activity levels, SRY increases MAO A-promoter activity up to 6fold in a concentration-dependent manner, overview. Sp1 synergistically enhances the SRY binding to and activation of the MAO A promoter by interacting and forming a transcriptional regulatory complex with SRY at the MAO A core promoter in vivo, Sp4 activates the MAO A core promoter as Sp1. Sp3 represses this activation by competing with Sp1 and Sp4 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | abnormal MAO A activity is implicated in several neuropsychiatric disorders, such as depression, autism, and attention deficit hyperactivity disorder, which show sexual dimorphism | Homo sapiens |
physiological function | MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions | Homo sapiens |