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Literature summary for 1.4.3.4 extracted from

  • Wu, J.B.; Chen, K.; Li, Y.; Lau, Y.F.; Shih, J.C.
    Regulation of monoamine oxidase A by the SRY gene on the Y chromosome (2009), FASEB J., 23, 4029-4038.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
SRY protein SRY and Sp1 form a transcriptional complex and synergistically activate MAO A transcription, overview Homo sapiens
transcription factor Sp1 SRY and Sp1 form a transcriptional complex and synergistically activate MAO A transcription, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
MAO A is encoded on the X chromosome Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information successful SRY knockdown inhibits MAO A catalytic activity by 45% Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
serotonin + H2O + O2 Homo sapiens MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin. MAO A is a putative target gene directly regulated by a transcription factor encoded by the sex-determining region Y, SRY, gene located on the Y chromosome, via the functional SRY-binding site in the MAO A core promoter (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
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-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
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Homo sapiens
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SK-N-BE(2)C cell male cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
serotonin + H2O + O2
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Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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?
serotonin + H2O + O2 MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin. MAO A is a putative target gene directly regulated by a transcription factor encoded by the sex-determining region Y, SRY, gene located on the Y chromosome, via the functional SRY-binding site in the MAO A core promoter Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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?

Synonyms

Synonyms Comment Organism
MAO A
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Homo sapiens
monoamine oxidase A
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a knockdown of SRY expression substantially reduces both MAO A 2- and 0.24-kb core-promoter activities to below 40% in the transfected cells, overview. R1, i.e. RAM2/CDCA7L/JPO2, a transcription repressor, downregulates MAO A gene expression by competing with Sp1 for binding to Sp1 sites down
Homo sapiens stable overexpression of SRY in the BE(2)C cell line results in ibncreased MAO-A mRNA and catalytic activity levels, SRY increases MAO A-promoter activity up to 6fold in a concentration-dependent manner, overview. Sp1 synergistically enhances the SRY binding to and activation of the MAO A promoter by interacting and forming a transcriptional regulatory complex with SRY at the MAO A core promoter in vivo, Sp4 activates the MAO A core promoter as Sp1. Sp3 represses this activation by competing with Sp1 and Sp4 up

General Information

General Information Comment Organism
malfunction abnormal MAO A activity is implicated in several neuropsychiatric disorders, such as depression, autism, and attention deficit hyperactivity disorder, which show sexual dimorphism Homo sapiens
physiological function MAO A catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions Homo sapiens