Literature summary for 1.4.3.5 extracted from

Kwak, S.E.; Kim, J.E.; Kim, D.W.; Kwon, O.S.; Choi, S.Y.; Kang, T.C.
Enhanced pyridoxal 5-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus (2009), Neuroscience, 159, 1108-1118.

Search for more literature for 1.4.3.5

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
dentate gyrus	-	Rattus norvegicus	-
granule cell	-	Rattus norvegicus	-
hippocampus	PNPO immunoreactivities are significantly increased in the rat hippocampus accompanied by reductions in paired-pulse inhibition at 1 day and 1 week after status epilepticus	Rattus norvegicus	-
additional information	immunohistochemic analysis, overview	Rattus norvegicus	-
neuron	-	Rattus norvegicus	-
pyramidal cell	Cornu Ammonis 1 pyramidal cells	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PNPO	-	Rattus norvegicus
pyridoxal 5'-phosphate synthetic enzyme	-	Rattus norvegicus
pyridoxine-5'-phosphate oxidase	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	PNPO immunoreactivities are significantly increased in the rat hippocampus accompanied by reductions in paired-pulse inhibition at 1 day and 1 week after status epilepticus	up

General Information

General Information	Comment	Organism
additional information	neurological diseases lead to upregulation of PNPO, immunoreactivities are mainly increased in glutamatergic principal neurons, dentate granule cells and CA1 pyramidal cells, and astrocytes independently of 4-aminobutyric acid levels, overview	Rattus norvegicus
physiological function	upregulation of PNPO expression may be involved in dendritic spine reorganization, which in turn, promotes the reverberation of recurrent excitatory networks in the hippocampus following status epilepticus. Activity-dependent regulation of PLP synthetic enzyme levels may play a role in tissue excitability in the hippocampus via various pathways	Rattus norvegicus

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Release 2023.1 (January 2023)