Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.9.2 extracted from

  • Kondo, T.; Kondo, E.; Maki, H.; Yasumoto, K.; Takagi, K.; Kano, K.; Ikeda, T.
    Purification and characterization of aromatic amine dehydrogenase from Alcaligenes xylosoxidans (2004), Biosci. Biotechnol. Biochem., 68, 1921-1928.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
8-hydroxyquinoline 33% inhibition at 1 mM Achromobacter xylosoxidans
beta-phenylethylamine substrate inhibition at higher concentrations Achromobacter xylosoxidans
dopamine substrate inhibition at higher concentrations Achromobacter xylosoxidans
EDTA 13% inhibition at 1 mM Achromobacter xylosoxidans
histamine weak substrate inhibition above 1 mM Achromobacter xylosoxidans
hydrazine complete inhibition at 0.1 mM Achromobacter xylosoxidans
hydroxylamine 99% inhibition at 1 mM Achromobacter xylosoxidans
iodoacetamide 28% inhibition at 1 mM Achromobacter xylosoxidans
monoiodoacetate 15% inhibition at 1 mM Achromobacter xylosoxidans
NaN3 30% inhibition at 1 mM Achromobacter xylosoxidans
o-phenanthroline 17% inhibition at 1 mM Achromobacter xylosoxidans
Semicarbazide 97% inhibition at 1 mM Achromobacter xylosoxidans
serotonin substrate inhibition at higher concentrations Achromobacter xylosoxidans
tryptamine substrate inhibition at higher concentrations Achromobacter xylosoxidans
tyramine substrate inhibition at higher concentrations Achromobacter xylosoxidans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
beta-phenylethylamine pH 7.5, 30°C Achromobacter xylosoxidans
0.0069
-
tyramine pH 7.5, 30°C Achromobacter xylosoxidans
0.048
-
phenazine methosulfate pH 7.5, 30°C Achromobacter xylosoxidans
0.171
-
histamine pH 7.5, 30°C Achromobacter xylosoxidans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15200
-
2 * 42300, alpha-subunit, + 2 * 15200, beta-subunit, SDS-PAGE Achromobacter xylosoxidans
42300
-
2 * 42300, alpha-subunit, + 2 * 15200, beta-subunit, SDS-PAGE Achromobacter xylosoxidans
95500
-
gel filtration Achromobacter xylosoxidans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol Achromobacter xylosoxidans
-
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol Achromobacter xylosoxidans IFO13495
-
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?

Organism

Organism UniProt Comment Textmining
Achromobacter xylosoxidans
-
-
-
Achromobacter xylosoxidans IFO13495
-
-
-

Purification (Commentary)

Purification (Comment) Organism
61fold to homogeneity, multistep procedure Achromobacter xylosoxidans

Reaction

Reaction Comment Organism Reaction ID
ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin ping-pong mechanism Achromobacter xylosoxidans

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:beta-phenylethylamine-grown cell
-
Achromobacter xylosoxidans
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.05
-
purified enzyme Achromobacter xylosoxidans

Storage Stability

Storage Stability Organism
4°C, purified enzyme, phosphate buffer, pH 7.0, stable for at least 1 month Achromobacter xylosoxidans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3-diaminopropane + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
1,3-diaminopropane + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans IFO13495 ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
1,6-diaminohexane + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
1,6-diaminohexane + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans IFO13495 ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans IFO13495 phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
butylamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans butanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
butylamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans IFO13495 butanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
cadaverine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
dopamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans (3,4-dihydroxyphenyl)acetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
hexylamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans hexanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
histamine + H2O + 2,6-dichlorophenol indophenol high activity at substrate concentration 1 mM Achromobacter xylosoxidans 1H-imidazol-4-ylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
additional information substrate specificity, overview, no activity with methylamine, dimethylamine, and trimethylamine Achromobacter xylosoxidans ?
-
?
additional information substrate specificity, overview, no activity with methylamine, dimethylamine, and trimethylamine Achromobacter xylosoxidans IFO13495 ?
-
?
pentylamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans pentanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
propylamine + H2O + 2,6-dichlorophenol indophenol low activity Achromobacter xylosoxidans propanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
putrescine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans 4-aminobutanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
serotonin + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans 6-hydroxy-4H-indol-3-yl-acetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
spermidine + H2O + 2,6-dichlorophenol indophenol low activity Achromobacter xylosoxidans ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
spermine + H2O + 2,6-dichlorophenol indophenol low activity Achromobacter xylosoxidans ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
tryptamine + H2O + 2,6-dichlorophenol indophenol
-
Achromobacter xylosoxidans 4H-indol-3-yl-acetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?
tyramine + H2O + 2,6-dichlorophenol indophenol best substrate Achromobacter xylosoxidans 4-hydroxyphenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
?

Subunits

Subunits Comment Organism
tetramer 2 * 42300, alpha-subunit, + 2 * 15200, beta-subunit, SDS-PAGE Achromobacter xylosoxidans

Synonyms

Synonyms Comment Organism
AADH
-
Achromobacter xylosoxidans
aromatic amine dehydrogenase
-
Achromobacter xylosoxidans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
-
Achromobacter xylosoxidans

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 80
-
Achromobacter xylosoxidans

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
40 min, stable, no loss of activity Achromobacter xylosoxidans
80
-
10 min, loss of 20% activity Achromobacter xylosoxidans
100
-
10 min, inactivation Achromobacter xylosoxidans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Achromobacter xylosoxidans

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 12
-
Achromobacter xylosoxidans

Cofactor

Cofactor Comment Organism Structure
tryptophan tryptophylquinone
-
Achromobacter xylosoxidans