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Literature summary for 1.5.1.10 extracted from
- Aminoadipic semialdehyde-glutamate reductase (1971), Methods Enzymol., 17B, 121-124.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-hydroxymercuribenzoate | - |
Saccharomyces cerevisiae |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.22 | - |
NADP+ | - |
Saccharomyces cerevisiae | |
| 0.92 | - |
saccharopine | - |
Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 73000 | - |
density gradient centrifugation | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
baker's yeast | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH | - |
Saccharomyces cerevisiae | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
saccharopine formation | Saccharomyces cerevisiae |
| 10 | - |
saccharopine degradation | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | NAD+ and NADP+ equally effective in 2-aminoadipate 6-semialdehyde formation | Saccharomyces cerevisiae | |
| NADH | NADPH far more effective than NADH in saccaropine formation | Saccharomyces cerevisiae | |
| NADP+ | NAD+ and NADP+ equally effective in 2-aminoadipate 6-semialdehyde formation | Saccharomyces cerevisiae | |
| NADPH | far more effective than NADH in saccharopine formation | Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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