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Literature summary for 1.5.1.15 extracted from

  • Mackenzie, R.E.; Mejia, N.; Yang, X.M.
    Methylenetetrahydrofolate dehydrogenases in normal and transformed mammalian cells (1988), Adv. Enzyme Regul., 27, 31-39.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
cytoplasm
-
Homo sapiens 5737
-
cytoplasm
-
Saccharomyces cerevisiae 5737
-
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Saccharomyces cerevisiae 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus
Mg2+
-
Homo sapiens
Mn2+
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
-
Homo sapiens
34000
-
SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-5,10-methenyl-tetrahydrofolate + NADH Mus musculus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH Homo sapiens
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH Saccharomyces cerevisiae
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methylenetetrahydrofolate + NAD+ Mus musculus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+ Homo sapiens
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+ Saccharomyces cerevisiae
-
5,10-methenyl-tetrahydrofolate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Mus musculus
-
-
-
Saccharomyces cerevisiae
-
yeast
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4
-
cutaneous melanoma Homo sapiens
2.7
-
fibroblast Mus musculus
3.4
-
embryo fibroblast Mus musculus
4.7
-
osteosarcoma Homo sapiens
5.5
-
mastocytoma Mus musculus
6.9
-
breast carcinoma Homo sapiens
7.8
-
leukemia Homo sapiens
8.9
-
adenocarcinoma Homo sapiens
9.4
-
T-cell lymphoma Mus musculus
9.7
-
lymphoma Mus musculus
12.9
-
embryonal carcinoma Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-5,10-methenyl-tetrahydrofolate + NADH
-
Mus musculus L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH
-
Homo sapiens L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methenyl-tetrahydrofolate + NADH
-
Saccharomyces cerevisiae L-5,10-methylenetetrahydrofolate + NAD+
-
r
L-5,10-methylenetetrahydrofolate + NAD+
-
Mus musculus 5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+
-
Homo sapiens 5,10-methenyl-tetrahydrofolate + NADH
-
r
L-5,10-methylenetetrahydrofolate + NAD+
-
Saccharomyces cerevisiae 5,10-methenyl-tetrahydrofolate + NADH
-
r

Subunits

Subunits Comment Organism
dimer
-
Mus musculus
dimer
-
Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
-
Mus musculus
methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Saccharomyces cerevisiae
NAD+ Ehrlich ascites tumor cells contains 2 enzymes, NAD+ dependent and NADP+ dependent dehydrogenase Mus musculus