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Literature summary for 1.5.1.15 extracted from

  • Takeya, C.; Esumi, M.; Shiroishi, T.; Hishida, R.; Yamamoto, T.
    Multiple single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase and its truncated pseudogene of 23 inbred strains of mice (2003), Biochem. Biophys. Res. Commun., 312, 480-486.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-methionine allosteric inhibitor, enzyme contains a binding site at the C-terminus Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme deficiency results in a number of diseases ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WU20 gene mthfr
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + NAD+ N-terminal catalytic domain Mus musculus 5,10-methenyltetrahydrofolate + NADH
-
?
additional information enzyme deficiency results in a number of diseases Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
5,10-methylenetetrahydrofolate reductase
-
Mus musculus
MTHFR
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
FAD required for enzyme stability, binding site comprises amino acid residues 95-228 Mus musculus
NAD+
-
Mus musculus