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Literature summary for 1.5.1.20 extracted from

  • McNulty, H.; McKinley, M.C.; Wilson, B.; McPartlin, J.; Strain, J.J.; Weir, D.G.; Scott, J.M.
    Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements (2002), Am. J. Clin. Nutr., 76, 436-441.
    View publication on PubMed
Search for more literature for 1.5.1.20

Protein Variants

Protein Variants Comment Organism
additional information C677T mutation of the gene for methylenetetrahydrofolate reductase: thermolabile enzyme with reduced activity, due to the loss of its riboflavin cofactor, homozygous genotype TT is associated with an increase in plasma total homocysteine, 12% of the healthy white population with this polymorphism Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + reduced acceptor Homo sapiens supply of the folate needed for the metabolism of homocysteine: 5-methyltetrahydrofolate is required for the methylation of homocysteine to methionine 5-methyltetrahydrofolate + oxidized acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 healthy men and women aged 19-63 years
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + reduced acceptor forward reaction: reduced acceptor is FADH2 Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
 ?
5,10-methylenetetrahydrofolate + reduced acceptor supply of the folate needed for the metabolism of homocysteine: 5-methyltetrahydrofolate is required for the methylation of homocysteine to methionine Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD requires FAD as cofactor Homo sapiens
FADH2
-
 Homo sapiens