Literature summary for 1.5.1.20 extracted from

Guerreiro, C.S.; Carmona, B.; Goncalves, S.; Carolino, E.; Fidalgo, P.; Brito, M.; Leitao, C.N.; Cravo, M.
Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients (2008), Am. J. Clin. Nutr., 88, 1413-1418.

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Application

Application	Comment	Organism
medicine	homozygosity for the C677T natural polymorphism presents a 3fold increased risk of colorectal cancer. Low intake of methyl-donor nutrients is associated with an increased risk of colorectal cancer in homozygous participants for the C677T polymorphism	Homo sapiens
nutrition	homozygosity for the C677T natural polymorphism presents a 3fold increased risk of colorectal cancer. Low intake of methyl-donor nutrients is associated with an increased risk of colorectal cancer in homozygous participants for the C677T polymorphism	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C677T	natural polymorphism. Homozygosity for the C677T variant presents a 3fold increased risk of colorectal cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with colorectal cancer	-

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Release 2023.1 (January 2023)