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Literature summary for 1.5.1.23 extracted from
- Characterization and physiological role of tauropine dehydrogenase and lactate dehydrogenase from muscle of abalone, Haliotis discus hannai (1991), Tohoku J. Agric. Res., 41, 83-95.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoate) | sulfhydryl reagents restore activity | Haliotis discus hannai |  |
| Cu2+ | - |
Haliotis discus hannai | |
| Fe2+ | - |
Haliotis discus hannai | |
| Fluorescein mercuric acetate | sulfhydryl reagents restore activity | Haliotis discus hannai | |
| Hg2+ | - |
Haliotis discus hannai | |
| NAD+ | - |
Haliotis discus hannai | |
| pyruvate | substrate inhibition above 8 mM | Haliotis discus hannai | |
| tauropine | - |
Haliotis discus hannai | |
| Zn2+ | - |
Haliotis discus hannai | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.071 | - |
NADH | - |
Haliotis discus hannai | |
| 3.6 | - |
2-oxovalerate | pyruvate | Haliotis discus hannai | |
| 44.4 | - |
taurine | - |
Haliotis discus hannai | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
gel filtration | Haliotis discus hannai |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Haliotis discus hannai | the enzyme plays an important physiological role in energy production during shell fixation activity in the columnella muscle | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haliotis discus hannai | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Haliotis discus hannai |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| columella muscle | upper part | Haliotis discus hannai | - |
| foot muscle | - |
Haliotis discus hannai | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Haliotis discus hannai |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala + pyruvate + NADH | about 2% of the activity with taurine | Haliotis discus hannai | ? | - |
? | |
| additional information | the enzyme plays an important physiological role in energy production during shell fixation activity in the columnella muscle | Haliotis discus hannai | ? | - |
? | |
| Taurine + 2-oxopentanoate + NADH | - |
Haliotis discus hannai | ? | - |
? | |
| Taurine + pyruvate + NADH | r | Haliotis discus hannai | Tauropine + NAD+ + H2O | - |
? | |
| Taurine + pyruvate + NADH | no activity with NADPH | Haliotis discus hannai | Tauropine + NAD+ + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 42000, SDS-PAGE | Haliotis discus hannai |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Haliotis discus hannai |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
tauropine formation | Haliotis discus hannai |
| 10 | - |
tauropine oxidation | Haliotis discus hannai |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | no activity with NADPH | Haliotis discus hannai | |
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