Literature summary for 1.5.1.3 extracted from

Bolin, J.T.; Filman, D.J.; Matthews, D.A.; Hamlin, R.C.; Kraut, J.
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate (1982), J. Biol. Chem., 257, 13650-13662.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of complex with methotrexate	Escherichia coli
structure of ternary complex with NADPH and methotrexate	Lacticaseibacillus casei

Inhibitors

Inhibitors	Comment	Organism	Structure
methotrexate	structure	Escherichia coli
methotrexate	structure	Lacticaseibacillus casei

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Lacticaseibacillus casei	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+	pteridine-binding site	Lacticaseibacillus casei	a

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Release 2023.1 (January 2023)