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Literature summary for 1.5.1.3 extracted from

  • D'Souza, L.; Warwick, P.E.; Freisheim, J.H.
    Purification and properties of dihydrofolate reductase from an amethopterin-resistant strain of Streptococcus faecium (1972), Biochemistry, 11, 1528-1534.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
methopterin
-
Enterococcus faecium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Enterococcus faecium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
sedimentation equilibrium analysis and gel filtration Enterococcus faecium

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
amethopterin-resistant strain
-

Purification (Commentary)

Purification (Comment) Organism
amethopterin-resistant strain Enterococcus faecium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
300
-
amethopterin-resistant cells, purified enzyme Enterococcus faecium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydrofolate + NADPH
-
Enterococcus faecium 5,6,7,8-tetrahydrofolate + NADP+
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
100
-
7,8-dihydrofolate form I Enterococcus faecium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Enterococcus faecium

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Enterococcus faecium