Literature summary for 1.5.1.3 extracted from

Hamel, M.J.; Poe, A.; Bloland, P.; McCollum, A.; Zhou, Z.; Shi, Y.P.; Ouma, P.; Otieno, K.; Vulule, J.; Escalante, A.; Udhayakumar, V.; Slutsker, L.
Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L mutation (2008), Trans. R. Soc. Trop. Med. Hyg., 102, 338-345.

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Application

Application	Comment	Organism
medicine	study on the effect of co-trimoxazole prophylaxis on Plasmodium falciparum antifolate resistance development among HIV-infected persons. Mutation I164L is not associated with high-level sulfadoxine-pyrimethamine resistance or poor outcome among adults living where malaria is highly endemic	Plasmodium falciparum

Protein Variants

Protein Variants	Comment	Organism
I164L	mutation I164L is not associated with high-level sulfadoxine-pyrimethamine resistance or poor outcome among infected adults living where malaria is highly endemic	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	isolated from infected Kenyan adults	-

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Release 2023.1 (January 2023)