Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoic acid | - |
Homo sapiens | |
4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoic acid | - |
Trypanosoma cruzi | |
5-(5-[[(2,4-diamino-6-quinazolinyl)methyl](propyl)amino]-2-methoxyphenoxy) pentanoate | - |
Homo sapiens | |
5-(5-[[(2,4-diamino-6-quinazolinyl)methyl](propyl)amino]-2-methoxyphenoxy) pentanoate | - |
Trypanosoma cruzi | |
6-[(3,4-dimethoxyanilino)methyl]-2,4-quinazolinediamine | - |
Homo sapiens | |
6-[(3,4-dimethoxyanilino)methyl]-2,4-quinazolinediamine | - |
Trypanosoma cruzi | |
ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoate | - |
Homo sapiens | |
ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoate | - |
Trypanosoma cruzi | |
methyl 4-[(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) methyl]benzene carboxylate | - |
Homo sapiens | |
methyl 4-[(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) methyl]benzene carboxylate | - |
Trypanosoma cruzi | |
methyl 5-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) pentanoate | - |
Homo sapiens | |
methyl 5-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) pentanoate | - |
Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00374 | - |
- |
Trypanosoma cruzi | Q27793 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Homo sapiens |
DHFR | - |
Trypanosoma cruzi |
dihydrofolate reductase | - |
Homo sapiens |
dihydrofolate reductase | - |
Trypanosoma cruzi |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22.6 | - |
assay at | Homo sapiens |
22.6 | - |
assay at | Trypanosoma cruzi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Trypanosoma cruzi |
7.3 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000013 | - |
ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoate | pH 7, 22.6°C | Trypanosoma cruzi | |
0.0000016 | - |
6-[(3,4-dimethoxyanilino)methyl]-2,4-quinazolinediamine | pH 7, 22.6°C | Trypanosoma cruzi | |
0.0000016 | - |
methyl 5-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) pentanoate | pH 7, 22.6°C | Trypanosoma cruzi | |
0.0000033 | - |
methyl 4-[(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) methyl]benzene carboxylate | pH 7, 22.6°C | Trypanosoma cruzi | |
0.0000036 | - |
4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoic acid | pH 7, 22.6°C | Trypanosoma cruzi | |
0.0000096 | - |
ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoate | pH 7.3, 22.6°C | Homo sapiens | |
0.0000118 | - |
6-[(3,4-dimethoxyanilino)methyl]-2,4-quinazolinediamine | pH 7.3, 22.6°C | Homo sapiens | |
0.000013 | - |
methyl 5-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) pentanoate | pH 7.3, 22.6°C | Homo sapiens | |
0.000024 | - |
5-(5-[[(2,4-diamino-6-quinazolinyl)methyl](propyl)amino]-2-methoxyphenoxy) pentanoate | pH 7, 22.6°C | Trypanosoma cruzi | |
0.000024 | - |
methyl 4-[(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) methyl]benzene carboxylate | pH 7.3, 22.6°C | Homo sapiens | |
0.000049 | - |
4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoic acid | pH 7.3, 22.6°C | Homo sapiens | |
0.000188 | - |
5-(5-[[(2,4-diamino-6-quinazolinyl)methyl](propyl)amino]-2-methoxyphenoxy) pentanoate | pH 7.3, 22.6°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000238 | - |
pH 7, 22.6°C | Trypanosoma cruzi | ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoate | |
0.000027 | - |
pH 7, 22.6°C | Trypanosoma cruzi | methyl 5-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) pentanoate | |
0.0000271 | - |
pH 7, 22.6°C | Trypanosoma cruzi | 6-[(3,4-dimethoxyanilino)methyl]-2,4-quinazolinediamine | |
0.0000575 | - |
pH 7, 22.6°C | Trypanosoma cruzi | methyl 4-[(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) methyl]benzene carboxylate | |
0.000061 | - |
pH 7, 22.6°C | Trypanosoma cruzi | 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoic acid | |
0.0000683 | - |
pH 7.3, 22.6°C | Homo sapiens | ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoate | |
0.0000855 | - |
pH 7.3, 22.6°C | Homo sapiens | 6-[(3,4-dimethoxyanilino)methyl]-2,4-quinazolinediamine | |
0.0000935 | - |
pH 7.3, 22.6°C | Homo sapiens | methyl 5-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) pentanoate | |
0.000174 | - |
pH 7.3, 22.6°C | Homo sapiens | methyl 4-[(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) methyl]benzene carboxylate | |
0.000356 | - |
pH 7.3, 22.6°C | Homo sapiens | 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy) butanoic acid | |
0.000422 | - |
pH 7, 22.6°C | Trypanosoma cruzi | 5-(5-[[(2,4-diamino-6-quinazolinyl)methyl](propyl)amino]-2-methoxyphenoxy) pentanoate | |
0.001338 | - |
pH 7.3, 22.6°C | Homo sapiens | 5-(5-[[(2,4-diamino-6-quinazolinyl)methyl](propyl)amino]-2-methoxyphenoxy) pentanoate |