Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | - |
Candida albicans | |
5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | - |
[Candida] glabrata | |
5-[3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | - |
Candida albicans | |
5-[3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | - |
[Candida] glabrata | |
5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | - |
Candida albicans | |
5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | - |
[Candida] glabrata | |
5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | - |
Candida albicans | |
5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | - |
[Candida] glabrata | |
5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | - |
Candida albicans | |
5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | - |
[Candida] glabrata | |
5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | - |
Candida albicans | |
5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | - |
[Candida] glabrata | |
6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
Candida albicans | |
6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
[Candida] glabrata | |
6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl]pyrimidine-2,4-diamine | - |
Candida albicans | |
6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl]pyrimidine-2,4-diamine | - |
[Candida] glabrata | |
6-ethyl-5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
Candida albicans | |
6-ethyl-5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
[Candida] glabrata | |
6-ethyl-5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
Candida albicans | |
6-ethyl-5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
[Candida] glabrata | |
6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
Candida albicans | |
6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine | - |
[Candida] glabrata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | Candida albicans | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | [Candida] glabrata | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
[Candida] glabrata | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | - |
Candida albicans | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | - |
[Candida] glabrata | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Candida albicans |
DHFR | - |
[Candida] glabrata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Candida albicans | |
NADPH | - |
[Candida] glabrata |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0006 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 5-[3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | |
0.0082 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | |
0.011 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.011 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.016 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.017 | - |
pH and temperature not specified in the publication | Candida albicans | 6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.018 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | |
0.019 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | |
0.02 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | |
0.021 | - |
pH and temperature not specified in the publication | Candida albicans | 5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | |
0.022 | - |
pH and temperature not specified in the publication | Candida albicans | 5-[3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | |
0.022 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 6-ethyl-5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.023 | - |
pH and temperature not specified in the publication | Candida albicans | 6-ethyl-5-[3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.023 | - |
pH and temperature not specified in the publication | Candida albicans | 5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | |
0.033 | - |
pH and temperature not specified in the publication | Candida albicans | 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.06 | - |
pH and temperature not specified in the publication | Candida albicans | 6-ethyl-5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.061 | - |
pH and temperature not specified in the publication | Candida albicans | 5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | |
0.071 | - |
pH and temperature not specified in the publication | Candida albicans | 6-ethyl-5-[3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.078 | - |
pH and temperature not specified in the publication | Candida albicans | 5-[3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | |
0.089 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 6-ethyl-5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine | |
0.097 | - |
pH and temperature not specified in the publication | [Candida] glabrata | 5-[3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | |
0.1 | - |
pH and temperature not specified in the publication | Candida albicans | 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine |