Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aminopterin | 0.025 mM, 50% inhibition of NADH-specific enzyme, 1 mM, 50% inhibition of NADPH-specific enzyme | Bos taurus | |
methopterin | 0.038 mM, 50% inhibition of NADH-specific enzyme | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00079 | - |
NADH | reduction of quinonoid 7,8-dihydro-6-methylpterin | Bos taurus | |
0.0011 | - |
quinonoid 7,8-dihydrobiopterin | cofactor NADPH | Bos taurus | |
0.0015 | - |
NADH | reduction of quinonoid 7,8-dihydrobiopterin | Bos taurus | |
0.0016 | - |
quinonoid 7,8-dihydrobiopterin | cofactor NADH | Bos taurus | |
0.0056 | - |
quinonoid 7,8-dihydro-6-methylpterin | cofactor NADH | Bos taurus | |
0.0058 | - |
quinonoid 7,8-dihydro-6-methylpterin | cofactor NADPH | Bos taurus | |
0.074 | - |
NADPH | reduction of quinonoid 7,8-dihydrobiopterin | Bos taurus | |
0.095 | - |
NADPH | reduction of quinonoid 7,8-dihydrobiopterin | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
2 * 25000, NADH-dihydropteridine reductase | Bos taurus |
49000 | 50000 | NADH-dihydropteridine reductase | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
70.7 | - |
NADH-specific enzyme | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H | - |
Bos taurus | 6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+ | - |
? | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | - |
Bos taurus | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? | |
quinonoid dihydrobiopterin + NADH + H+ | - |
Bos taurus | 6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 25000, NADH-dihydropteridine reductase | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | utilizes both NADH and NADPH | Bos taurus | |
NADH | enzyme prefers NADH | Bos taurus | |
NADH | liver: 2 distinct dihydropteridine reductases which catalyze the conversion of the quinonoid dihydropteridine to tetrahydropterin: NADH-dihydropteridine reductase, DPR, utilizes NADH as a better substrate than NADPH, NADPH-specific dihydropteridine reductase, TPR, shows strict specificity for NADPH | Bos taurus | |
NADPH | utilizes both NADH and NADPH | Bos taurus | |
NADPH | liver: 2 distinct dihydropteridine reductases which catalyze the conversion of the quinonoid dihydropteridine to tetrahydropterin: NADH-dihydropteridine reductase, DPR, utilizes NADH as a better substrate than NADPH, NADPH-specific dihydropteridine reductase, TPR, shows strict specificity for NADPH | Bos taurus | |
NADPH | NADH is preferred | Bos taurus |