Protein Variants | Comment | Organism |
---|---|---|
A133S | - |
Rattus norvegicus |
Y146F | - |
Rattus norvegicus |
Y146F/A133S | almost no activity with quinonoid 6,7-dimethyldihydropteridine, higher activity with quinoid dihydrobipterin than wild-type | Rattus norvegicus |
Y146F/K150E | no activity with quinonoid 6,7-dimethyldihydropteridine, higher activity with quinoid dihydrobipterin than wild-type | Rattus norvegicus |
Y146H | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
quinonoid dihydrobiopterin | recombinant wild-type enzyme | Rattus norvegicus | |
0.0004 | - |
quinonoid dihydrobiopterin | A133S mutant enzyme | Rattus norvegicus | |
0.002 | - |
NADH | Y146F/A133S mutant enzyme | Rattus norvegicus | |
0.003 | - |
NADH | Y146F mutant enzyme | Rattus norvegicus | |
0.007 | - |
quinonoid dihydrobiopterin | Y146H mutant enzyme | Rattus norvegicus | |
0.008 | - |
NADH | Y146H mutant enzyme | Rattus norvegicus | |
0.008 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | A133S mutant enzyme | Rattus norvegicus | |
0.013 | - |
NADH | recombinant wild-type enzyme | Rattus norvegicus | |
0.013 | - |
NADH | K150E mutant enzyme | Rattus norvegicus | |
0.022 | - |
NADH | A133S mutant enzyme | Rattus norvegicus | |
0.024 | - |
quinonoid dihydrobiopterin | Y146F/A133S mutant enzyme | Rattus norvegicus | |
0.027 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | recombinant wild-type enzyme | Rattus norvegicus | |
0.028 | - |
quinonoid dihydrobiobiopterin | K150E mutant enzyme | Rattus norvegicus | |
0.1 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | Y146F/A133S mutant enzyme | Rattus norvegicus | |
0.17 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | Y146H mutant enzyme | Rattus norvegicus | |
0.29 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | K150E mutant enzyme | Rattus norvegicus | |
0.308 | - |
quinonoid dihydrobiopterin | Y146F mutant enzyme | Rattus norvegicus | |
0.46 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | Y146F mutant enzyme | Rattus norvegicus | |
1 | - |
quinonoid dihydrobiopterin | Y146F/K150E mutant enzyme, more than | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinoid dihydrobiopterin + NAD(P)H | - |
Rattus norvegicus | tetrahydrobiopterin + NAD(P)+ | - |
? | |
quinonoid 6,7-dimethyl-7,8-dihydropteridine + NADH + H+ | - |
Rattus norvegicus | 6,7-dimethyl-5,6,7,8-tetrahydropteridine + NAD+ | - |
r | |
quinonoid dihydrobiopterin + NADH + H+ | - |
Rattus norvegicus | 6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+ | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | Y146F/A133S mutant enzyme | Rattus norvegicus | |
17 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | Y146F mutant enzyme | Rattus norvegicus | |
20 | - |
quinoid dihydrobiopterin | A133S mutant enzyme | Rattus norvegicus | |
23 | - |
quinoid dihydrobiopterin | recombinant wild-type enzyme | Rattus norvegicus | |
36 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | Y146H mutant enzyme | Rattus norvegicus | |
52 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | K150E mutant enzyme | Rattus norvegicus | |
74 | - |
quinoid dihydrobiopterin | Y146F/A133S mutant enzyme | Rattus norvegicus | |
138 | - |
quinoid dihydrobiopterin | Y146F mutant enzyme | Rattus norvegicus | |
139 | - |
quinoid dihydrobiopterin | Y146H mutant enzyme | Rattus norvegicus | |
152 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | A133S mutant enzyme | Rattus norvegicus | |
153 | - |
quinonoid 6,7-dimethyl-7,8-dihydropteridine | recombinant wild-type enzyme | Rattus norvegicus | |
200 | - |
quinoid dihydrobiopterin | Y146F/K150E mutant enzyme, approx. value | Rattus norvegicus | |
269 | - |
quinoid dihydrobiobiopterin | K150E mutant enzyme | Rattus norvegicus |