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Literature summary for 1.5.1.8 extracted from

  • Arruda, P.; Da Silva, W.J.
    Lysine-ketoglutarate reductase activity in maize: Its possible role in lysine metabolism of developing endosperm (1983), Phytochemistry, 22, 2687-2689.
No PubMed abstract available
Search for more literature for 1.5.1.8

Inhibitors

Inhibitors Comment Organism Structure
leucine slight inhibition Zea mays

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
 L-lysine
-
 Zea mays

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH Zea mays first step in lysine breakdown in the endosperm during seed development N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Zea mays
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Zea mays

Source Tissue

Source Tissue Comment Organism Textmining
endosperm during development Zea mays
-
endosperm enzyme activity increases with the onset of endosperm development with a peak at 20 days after pollination Zea mays
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Zea mays

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH specific for L-lysine, 2-oxoglutarate and NADPH Zea mays N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Zea mays N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH first step in lysine breakdown in the endosperm during seed development Zea mays N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH specific for NADPH Zea mays