Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.8 extracted from

  • Blemings, K.P.; Crenshaw, T.D.; Swick, R.W.; Benevenga, N.J.
    Lysine-alpha-ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver (1994), J. Nutr., 124, 1215-1221.
    View publication on PubMed
Search for more literature for 1.5.1.8

General Stability

General Stability Organism
Triton X-100 is necessary to observe maximal enzyme activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by Triton X-100 up to 2.5 ml/l Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix enzyme found only in the mitochondrial matrix Rattus norvegicus 5759
-
additional information not found in peroxisomes or lysosomes Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH Rattus norvegicus initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus