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Literature summary for 1.5.1.8 extracted from

  • Umair, S.; Bland, R.J.; Simpson, H.V.
    Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta (2012), Exp. Parasitol., 131, 101-106.
    View publication on PubMed
Search for more literature for 1.5.1.8

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
 L-lysine enzyme from L3 larva, at pH 7.0, temperature not specified in the publication Haemonchus contortus
0.5
-
 L-lysine enzyme from L3 larva, at pH 7.0, temperature not specified in the publication Teladorsagia circumcincta
0.7
-
 L-lysine enzyme from adult, at pH 7.0, temperature not specified in the publication Haemonchus contortus
0.9
-
 L-lysine enzyme from adult, at pH 7.0, temperature not specified in the publication Teladorsagia circumcincta

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 0.5 mM Ca+ used in assay conditions Haemonchus contortus
Ca2+ 0.5 mM Ca+ used in assay conditions Teladorsagia circumcincta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate + NADH + H+ Haemonchus contortus
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
L-lysine + 2-oxoglutarate + NADH + H+ Teladorsagia circumcincta
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
L-lysine + 2-oxoglutarate + NADPH + H+ Haemonchus contortus
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
L-lysine + 2-oxoglutarate + NADPH + H+ Teladorsagia circumcincta
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Haemonchus contortus
-
-
-
Teladorsagia circumcincta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adult
-
 Haemonchus contortus
-
adult
-
 Teladorsagia circumcincta
-
larva
-
 Haemonchus contortus
-
larva
-
 Teladorsagia circumcincta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoglutarate + NADH + H+
-
 Haemonchus contortus N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
L-lysine + 2-oxoglutarate + NADH + H+
-
 Teladorsagia circumcincta N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
L-lysine + 2-oxoglutarate + NADPH + H+
-
 Haemonchus contortus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
L-lysine + 2-oxoglutarate + NADPH + H+
-
 Teladorsagia circumcincta N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
LKR
-
 Haemonchus contortus
LKR
-
 Teladorsagia circumcincta
lysine ketoglutarate reductase
-
 Haemonchus contortus
lysine ketoglutarate reductase
-
 Teladorsagia circumcincta

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Haemonchus contortus
7
-
-
 Teladorsagia circumcincta

Cofactor

Cofactor Comment Organism Structure
NAD+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Haemonchus contortus
NAD+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Teladorsagia circumcincta
NADP+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Haemonchus contortus
NADP+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Teladorsagia circumcincta