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Literature summary for 1.5.3.1 extracted from
- Ionization of zwitterionic amine substrates bound to monomeric sarcosine oxidase (2005), Biochemistry, 44, 16866-16874.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y317F | 20fold decrease in the maxumim rate of the reductive half-reaction. Unlike wild-type, Kd-values of mutant are pH-dependent | Bacillus sp. (in: Bacteria) |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methylthioacetate | comparison of complexes with wild-type and mutant Y317F | Bacillus sp. (in: Bacteria) |  |
| pyrrole-2-carboxylate | comparison of complexes with wild-type and mutant Y317F | Bacillus sp. (in: Bacteria) | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus sp. (in: Bacteria) | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| sarcosine + H2O + O2 = glycine + formaldehyde + H2O2 | L-proline is the ionizable group in the ES complex. Y317 may play a role in substrate activation and optimizing of binding | Bacillus sp. (in: Bacteria) |
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