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Literature summary for 1.5.3.16 extracted from
- Properties of purified human polyamine oxidase, PAOh1/SMO (2003), Biochem. Biophys. Res. Commun., 304, 605-611.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition by N1-ethyl-N11-(cycloheptyl)methyl-4,8,diazaundecane | Homo sapiens | |
| N1,N4-bis(2,3-butadienyl)-1,4-butanediamine | i.e. MDL72527, 0.25 mM, more than 95% inhibition | Homo sapiens |  |
| SL-11144 | potent inhibitor of PAOh1/SMO, IC50 below 0.01 mM | Homo sapiens | |
| SL-11150 | potent inhibitor of PAOh1/SMO, IC50 below 0.01 mM | Homo sapiens | |
| SL-11158 | potent inhibitor of PAOh1/SMO, IC50 below 0.01 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00163 | - |
spermine | 37°C, pH 8.0 | Homo sapiens | |
| 0.051 | - |
N1-acetylspermine | 37°C, pH 8.0 | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
x * 64000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NWM0 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Homo sapiens |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| protein is first purified from the cell lysate under denaturing conditions and renatured by dialysis against decreasing concentrations of urea | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no activity with spermidine. No oxidation of N1,N11-bis(ethyl)norspemine, N1-ethyl-N11-(cyclopropyl)methyl-4,8,diazaundecane, N1-ethyl-N11-(cycloheptyl)methyl-4,8,diazaundecane, (S)-N1-(2-methyl-1-butyl)-N11-ethyl-4,8,diazaundecane, SL-11144, SL-11150, SL-11156 and SL-11093 | Homo sapiens | ? | - |
? | |
| N1-acetylspermine + O2 + H2O | weak activity | Homo sapiens | ? | - |
? | |
| spermine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 64000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAOh1/SMO | - |
Homo sapiens |
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