Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
spermine + O2 + H2O | Homo sapiens | - |
spermidine + 3-aminopropanal + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
mononuclear cell | mononuclear inflammatory cells | Homo sapiens | - |
additional information | immunohistochemic detection of enzyme expression in different tissue during inflammation, overview | Homo sapiens | - |
stomach | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
spermine + O2 + H2O | - |
Homo sapiens | spermidine + 3-aminopropanal + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMO | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | increased expression of spermine oxidase in ulcerative colitis and in prostate cancer and prostate intraepithelial neoplasia tissues. SMO expression is upregulated in gastritis tissues from patients with Helicobacter pylori infection, it is upregulated in both macrophages and epithelial cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | involvement of SMO in gastritic mucosal inflammation, SMO expression is increased in human prostate cancer and prostate intraepithelial neoplasia tissues. Polyamines are ubiquitous, polycationic alkylamines that are essential for eukaryotic cell growth and differentiation, and play an important role in inflammation-induced carcinogenesis. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity | Homo sapiens |