Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibited by 0.01 M benzoate, 0.01 M quinine HCl, 0.01 M atabrine, 0.01 M KCN | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.262 | - |
alpha-N-methyl-L-tryptophan | - |
Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2 | reaction mechanism | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-N-methyl-L-histidine + O2 + H2O | - |
Oryctolagus cuniculus | L-histidine + formaldehyde + H2O2 | - |
? | |
alpha-N-methyl-L-tryptophan + O2 + H2O | alpha-N-methyl-L-tryptophan is identical with L-abrine | Oryctolagus cuniculus | L-tryptophan + formaldehyde + H2O2 | - |
? | |
additional information | more substrates, not with: N-dimethyl-L-amino acid, N-methyl-D-amino acid, L-amino acid, D-amino acid | Oryctolagus cuniculus | ? | - |
? | |
N-methyl-L-amino acid + O2 + H2O | enzyme requires the presence of a free alpha-carboxyl group in the substrate molecule, substrates with aromatic or heterocyclic substituents are more readily oxidized, followed by aliphatic N-methylamino acids with long side chain, more slowly activity towards N-methyl derivatives of beta-hydroxy-amino acids and of basic and acidic amino acids with exception of histidin, very slow demethylation of phenylsarcosine | Oryctolagus cuniculus | L-amino acid + formaldehyde + H2O2 | - |
? | |
N-methyl-L-norleucine + O2 + H2O | - |
Oryctolagus cuniculus | L-norleucine + formaldehyde + H2O2 | - |
? | |
N-methyl-L-phenylalanine + O2 + H2O | - |
Oryctolagus cuniculus | L-phenylalanine + formaldehyde + H2O2 | - |
? | |
N-methyl-L-tyrosine + O2 + H2O | N-methyl-DL-tyrosine is identical with surinamine | Oryctolagus cuniculus | L-tyrosine + formaldehyde + H2O2 | - |
? | |
N-methyldihydroxyphenyl-DL-alanine + O2 + H2O | - |
Oryctolagus cuniculus | formaldehyde + dihydroxyphenyl-DL-alanine + H2O2 | - |
? | |
N-methylvanillyl-L-alanine + O2 + H2O | - |
Oryctolagus cuniculus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | as prosthetic group | Oryctolagus cuniculus |